Y-27632 dihydrochloride (CAS 129830-38-2)
See product citations (5)
QUICK LINKS
Y-27632 dihydrochloride monohydrate is a highly potent, cell-permeable, selective Rock (Rho-associated coiled coil forming protein serine/threonine kinase) inhibitor. Ki= 140 nM for p160 ROCK. It also inhibits ROCK-II with equal potency where the inhibition is competitive with respect to ATP. Y-27632 is a versatile research tool known for its range of biological effects, particularly in the field of stem cell research. It is employed as a key component in 3D growth matrices and brain organoid differentiation media. Notably, Y-27632 plays a role in the maintenance and differentiation of stem cells. Its use has been instrumental in enabling the survival and differentiation of human embryonic stem cells into cortical and basal telencephalic progenitors, thereby facilitating the study of developmental processes and potential therapeutic applications.
Y-27632 dihydrochloride (CAS 129830-38-2) References
- Degenerative muscle fiber accelerates adipogenesis of intramuscular cells via RhoA signaling pathway. | Hosoyama, T., et al. 2009. Differentiation. 77: 350-9. PMID: 19281783
- Myosin light chain phosphatase activation is involved in the hydrogen sulfide-induced relaxation in mouse gastric fundus. | Dhaese, I. and Lefebvre, RA. 2009. Eur J Pharmacol. 606: 180-6. PMID: 19374871
- Increased cell bond tension governs cell sorting at the Drosophila anteroposterior compartment boundary. | Landsberg, KP., et al. 2009. Curr Biol. 19: 1950-5. PMID: 19879142
- Vasorelaxant and antihypertensive effects of methanolic extract from roots of Laelia anceps are mediated by calcium-channel antagonism. | Vergara-Galicia, J., et al. 2010. Fitoterapia. 81: 350-7. PMID: 19879929
- The influence of substrate creep on mesenchymal stem cell behaviour and phenotype. | Cameron, AR., et al. 2011. Biomaterials. 32: 5979-93. PMID: 21621838
- Fine tuning of tissues' viscosity and surface tension through contractility suggests a new role for α-catenin. | Stirbat, TV., et al. 2013. PLoS One. 8: e52554. PMID: 23390488
- The effect of Rho-associated kinase inhibition on the proteome pattern of dissociated human embryonic stem cells. | Gharechahi, J., et al. 2014. Mol Biosyst. 10: 640-52. PMID: 24430196
- Derivation of Intestinal Organoids from Human Induced Pluripotent Stem Cells for Use as an Infection System. | Forbester, JL., et al. 2019. Methods Mol Biol. 1576: 157-169. PMID: 27576565
- Colonoscopy-based colorectal cancer modeling in mice with CRISPR-Cas9 genome editing and organoid transplantation. | Roper, J., et al. 2018. Nat Protoc. 13: 217-234. PMID: 29300388
- Interfollicular Epidermal Stem Cells: Boosting and Rescuing from Adult Skin. | Cerqueira, MT., et al. 2019. Methods Mol Biol. 1879: 101-110. PMID: 29980942
- Using Human Induced Pluripotent Stem Cell-derived Intestinal Organoids to Study and Modify Epithelial Cell Protection Against Salmonella and Other Pathogens. | Lees, EA., et al. 2019. J Vis Exp.. PMID: 31132035
- Identifying Cell-Type-Specific Metabolic Signatures Using Transcriptome and Proteome Analyses. | Gebert, N., et al. 2021. Curr Protoc. 1: e245. PMID: 34516047
- Direct Lineage Reprogramming for Induced Keratinocyte Stem Cells: A Potential Approach for Skin Repair. | Lin, H., et al. 2023. Stem Cells Transl Med.. PMID: 37018467
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Y-27632 dihydrochloride, 1 mg | sc-216067 | 1 mg | $170.00 | |||
Y-27632 dihydrochloride, 5 mg | sc-216067A | 5 mg | $430.00 |