EXOSC9 Activators
EXOSC9 Activators are a class of compounds that can enhance the activity of EXOSC9, a key component of the RNA exosome complex that plays a pivotal role in 3'-5' RNA processing and degradation. These chemicals, although diverse in their structures and primary targets, share a common feature of influencing the cyclic AMP (cAMP)-dependent signaling cascade, which can potentially lead to the functional activation of EXOSC9. This group of activators includes compounds that directly stimulate adenylate cyclase such as Forskolin and Cholera toxin, leading to an increase in the production of cAMP. Others act as inhibitors of phosphodiesterases, enzymes responsible for the breakdown of cAMP, resulting in elevated cAMP levels within the cell. Furthermore, some activators such as Epinephrine and Pertussis toxin indirectly modulate the activity of adenylate cyclase and phosphodiesterases through their interaction with specific cell receptors.
The increased concentration of cAMP in the cellular milieu leads to the activation of protein kinase A (PKA), a crucial enzyme that phosphorylates a variety of proteins, possibly including EXOSC9. Phosphorylation by PKA has the potential to enhance the functional activity of EXOSC9 in RNA processing and degradation. Notably, some compounds in this class inhibit PKA, which might paradoxically increase the pool of available phosphate groups for the phosphorylation and activation of EXOSC9. Therefore, despite their differences in action and targets, all these compounds converge on the same goal: enhancing the functionality of EXOSC9 in its role within the RNA exosome complex.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is a compound found in the plant Coleus forskohlii that directly activates adenylate cyclase, leading to an increase in cyclic AMP (cAMP) levels. The elevated cAMP activates protein kinase A (PKA), which can phosphorylate and activate EXOSC9, enhancing its function in RNA processing. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
This cAMP analog acts similarly to Forskolin. It increases cAMP levels in cells, activating PKA, which can phosphorylate EXOSC9, enhancing its RNA processing function. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-specific inhibitor of phosphodiesterases, enzymes that break down cAMP. By inhibiting these enzymes, IBMX raises cAMP levels in the cell, leading to PKA activation and subsequent EXOSC9 enhancement. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine is a hormone that binds to and activates beta-adrenergic receptors, leading to an increase in cAMP levels. The elevated cAMP activates PKA, which can phosphorylate and activate EXOSC9, enhancing its function in RNA processing. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase 4, which specifically breaks down cAMP. By inhibiting this enzyme, Rolipram increases cAMP levels, leading to PKA activation and subsequent EXOSC9 enhancement. | ||||||
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $94.00 $186.00 | 71 | |
H-89 is an inhibitor of PKA. By inhibiting PKA, it decreases the phosphorylation of many proteins, potentially increasing the availability of phosphate groups for EXOSC9 enhancement. | ||||||
Pertussis Toxin (islet-activating protein) | 70323-44-3 | sc-200837 | 50 µg | $451.00 | 3 | |
It inhibits Gi proteins, which normally inhibit adenylate cyclase. Inhibition of these Gi proteins by Pertussis toxin leads to an increase in cAMP, activating PKA and potentially enhancing EXOSC9 function. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic Acid is an inhibitor of protein phosphatases PP1 and PP2A. This could lead to an increase in the phosphorylation state of proteins, including EXOSC9, potentially enhancing its function. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
This is a potent inhibitor of protein kinases, including PKA. It could increase the availability of phosphate groups for EXOSC9 phosphorylation and activation. | ||||||
Vinpocetine | 42971-09-5 | sc-201204 sc-201204A sc-201204B | 20 mg 100 mg 15 g | $55.00 $214.00 $2400.00 | 4 | |
Vinpocetine is a selective inhibitor of phosphodiesterase 1. It increases cAMP and cGMP levels in the brain, potentially leading to PKA activation and subsequent EXOSC9 enhancement. | ||||||