EXOSC5 Inhibitors

EXOSC5 inhibitors are primarily chemicals known to interfere with RNA metabolic pathways, rather than directly targeting the EXOSC5 protein. Their mode of action leans heavily towards impacting RNA synthesis, maturation, or processing, potentially leading to changes in RNA degradation, where EXOSC5 plays a role. Chemicals such as α-Amanitin and DRB are potent inhibitors of RNA polymerase II, reducing RNA synthesis which can subsequently affect RNA degradation processes. Meanwhile, Cordycepin acts as an analog of adenosine, creating disruptions in RNA synthesis which can indirectly influence RNA degradation mechanisms.

On the other hand, a distinct group of inhibitors focuses on the RNA splicing machinery. Pladienolide B and Spliceostatin A are notable examples of spliceosome inhibitors. Their interruption of RNA maturation indirectly touches upon the overarching RNA metabolic pathway, which might have downstream effects on RNA degradation, implicating proteins like EXOSC5. Suramin and Mycophenolic acid, albeit being broad spectrum in their inhibitory profiles, can also affect RNA metabolism, thus having a potential impact on the degradation process.