Est1 Activators
Chemical activators classified as Est1 Activators are identified based on their ability to indirectly affect the telomerase complex's assembly, stability, and function. These chemicals either contribute to telomere length maintenance, enhance telomerase activity, or are involved in cellular mechanisms that respond to telomeric stress or damage, which can in turn impact the function and stabilization of Est1 within the telomerase complex. Such activators include saponins such as Astragaloside IV and Cycloastragenol, known to increase telomerase activity.
Additional molecules like GRN163L and BIBR1532 act as telomerase inhibitors, but their removal may lead to a rebound effect, transiently increasing telomerase activity. Nutrients essential for cellular functions, such as Zinc, Retinoic Acid, Vitamin D3, Selenium, and Resveratrol, can also support telomere maintenance mechanisms, thus indirectly modulating Est1 activity. In the context of cellular homeostasis and stress response, steroid compounds like Danazol can initiate signaling cascades that ultimately enhance telomerase complex activity, suggesting a potential rise in Est1 activity.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Astragaloside IV | 84687-43-4 | sc-257103 | 20 mg | $56.00 | 1 | |
A saponin found in Astragalus membranaceus that has been shown to increase telomerase activity, potentially influencing Est1. | ||||||
Danazol | 17230-88-5 | sc-203021 sc-203021A | 100 mg 250 mg | $90.00 $233.00 | 3 | |
A synthetic steroid that has been reported to increase telomerase activity in certain cell types, which may influence Est1. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
An essential mineral that can support telomerase activity; sufficient levels of zinc are necessary for the function of various cellular components, including those that may involve Est1. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
A metabolite of vitamin A that has been shown to influence telomerase activity and may impact Est1 by extension. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
It has been associated with telomere length maintenance and could indirectly affect Est1. | ||||||
Selenium | 7782-49-2 | sc-250973 | 50 g | $61.00 | 1 | |
An element known to contribute to antioxidant defense systems that protect telomeric DNA and could indirectly support Est1 function. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
A polyphenolic compound that could enhance telomerase activity and indirectly influence Est1. | ||||||