ESE-3A Activators
ESE-3A Activators comprise a class of compounds known to directly or indirectly enhance the functional activity of the ESE-3A protein. These compounds specifically interact with the ESE-3A protein or the related pathways to enhance its activity. A common mechanism of enhancing ESE-3A activity is through the modulation of intracellular cyclic AMP (cAMP) levels. Compounds such as Epinephrine, Forskolin, IBMX, Cholera Toxin, Dibutyryl-cAMP, Rolipram, and Vinpocetine can increase intracellular cAMP levels, leading to the activation of protein kinase A (PKA). Activated PKA can then phosphorylate and activate ESE-3A, therefore enhancing its function.
Other compounds such as PMA and Staurosporine can enhance ESE-3A function by activating protein kinase C (PKC), which can directly phosphorylate and activate ESE-3A. Moreover, H-89, Okadaic acid and Calyculin A can act indirectly by inhibiting the negative regulators of ESE-3A. H-89 inhibits PKA, while Okadaic acid and Calyculin A inhibit protein phosphatases PP1 and PP2A, which can dephosphorylate and deactivate ESE-3A. By inhibiting these negative regulators, these compounds maintain the activation and function of ESE-3A.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine can enhance ESE-3A activity by activating the adrenergic receptors and in turn increasing intracellular cAMP levels. This enhances the activity of protein kinase A (PKA) which can phosphorylate and activate ESE-3A, leading to an increase in its function. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is a potent activator of adenylyl cyclase, leading to increased cAMP production. The elevated cAMP levels enhance the activity of PKA, which can phosphorylate and activate ESE-3A, leading to increased ESE-3A function. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-specific phosphodiesterase inhibitor that prevents the degradation of cAMP, thereby increasing its levels. The elevated cAMP levels enhance the activity of PKA, which can phosphorylate and activate ESE-3A, leading to increased ESE-3A function. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC), which can phosphorylate and activate ESE-3A, leading to increased ESE-3A function. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl-cAMP is a cell-permeable cAMP analog that activates PKA. The activated PKA can phosphorylate and activate ESE-3A, leading to increased ESE-3A function. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases PP1 and PP2A. By inhibiting these phosphatases, okadaic acid prevents the dephosphorylation of ESE-3A, thus maintaining its activation and function. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A is a potent inhibitor of protein phosphatases PP1 and PP2A. By inhibiting these phosphatases, Calyculin A prevents the dephosphorylation of ESE-3A, thus maintaining its activation and function. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a potent PKC activator. Activated PKC can phosphorylate and activate ESE-3A, leading to increased ESE-3A function. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a selective phosphodiesterase-4 inhibitor, which prevents the degradation of cAMP, thereby increasing its levels. The elevated cAMP levels enhance the activity of PKA, which can phosphorylate and activate ESE-3A, leading to increased ESE-3A function. | ||||||
Vinpocetine | 42971-09-5 | sc-201204 sc-201204A sc-201204B | 20 mg 100 mg 15 g | $55.00 $214.00 $2400.00 | 4 | |
Vinpocetine is a selective phosphodiesterase-1 inhibitor, which prevents the degradation of cAMP, thereby increasing its levels. The elevated cAMP levels enhance the activity of PKA, which can phosphorylate and activate ESE-3A, leading to increased ESE-3A function. | ||||||