ESAT6 Activators
The chemical class of ESAT-6 Activators includes compounds that can indirectly influence ESAT-6 function through their effects on the bacterial environment, particularly in the context of stress responses and metabolic disruption. These compounds, while not directly interacting with ESAT-6, play significant roles in modulating the conditions under which Mycobacterium tuberculosis thrives and secretes virulence factors like ESAT-6.
Antibiotics such as Isoniazid, Rifampicin, and Ethambutol, which target various aspects of mycobacterial physiology, may indirectly impact ESAT-6 expression or secretion. The stress induced by these antibiotics on bacterial metabolism and cell wall synthesis could lead to a compensatory response that includes modulation of virulence factors like ESAT-6. Moreover, compounds that affect bacterial protein synthesis and energy metabolism, such as Streptomycin, Amikacin, and Bedaquiline, can influence the bacterial stress response, potentially affecting the expression or activity of ESAT-6. The alteration of the bacterial environment by these antibiotics might lead to changes in the expression of virulence factors as part of the bacterium's survival strategy.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isoniazid | 54-85-3 | sc-205722 sc-205722A sc-205722B | 5 g 50 g 100 g | $26.00 $101.00 $146.00 | ||
An antibiotic that targets mycobacterial cell wall synthesis, potentially causing stress that influences ESAT-6 expression. | ||||||
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $97.00 $328.00 $676.00 $1467.00 | 6 | |
An antibiotic affecting bacterial RNA synthesis, which may alter ESAT-6 expression through stress responses. | ||||||
Ethambutol | 74-55-5 | sc-205684 sc-205684A | 25 g 100 g | $412.00 $1161.00 | 1 | |
Targets arabinogalactan synthesis in mycobacteria, potentially affecting ESAT-6 expression indirectly. | ||||||
Pyrazinamide | 98-96-4 | sc-205824 sc-205824A sc-205824B sc-205824C sc-205824D sc-205824E | 10 g 25 g 100 g 250 g 1 kg 5 kg | $49.00 $67.00 $89.00 $151.00 $483.00 $2276.00 | ||
An antimycobacterial agent, its mechanism could induce stress responses affecting ESAT-6 expression. | ||||||
Streptomycin sulfate | 3810-74-0 | sc-202821 sc-202821A | 10 g 100 g | $92.00 $131.00 | 12 | |
An aminoglycoside antibiotic, which might influence ESAT-6 expression by affecting protein synthesis. | ||||||
Ciprofloxacin | 85721-33-1 | sc-217900 | 1 g | $43.00 | 8 | |
A fluoroquinolone that inhibits bacterial DNA gyrase, potentially influencing ESAT-6 through altered bacterial stress responses. | ||||||
D-Cycloserine | 68-41-7 | sc-221470 sc-221470A sc-221470B sc-221470C | 200 mg 1 g 5 g 25 g | $28.00 $77.00 $142.00 $530.00 | 4 | |
Targets cell wall synthesis in mycobacteria, potentially affecting ESAT-6 expression. | ||||||