Esa1 Inhibitors
Esa1, being a part of the MYST family of histone acetyltransferases, plays a pivotal role in the modulation of gene transcription through its acetylation activity in yeast. Esa1 inhibitors primarily focus on curtailing this acetylating ability. Among the notable inhibitors, Garcinol and Anacardic acid are directly involved in inhibiting Esa1's function by binding to its acetyl-CoA site or directly reducing its acetylation activity. Furthermore, the compound Curcumin can disrupt Esa1's interaction with acetyl-CoA, thereby reducing its catalytic efficiency.
Epigallocatechin gallate (EGCG) and synthetic compounds such as MB-3, PU139, and PU141 have shown to have a direct interaction with MYST family proteins, including Esa1, resulting in their inhibited enzymatic activity. Salermide, though known to primarily target sirtuins, might indirectly affect HATs like Esa1. On the broader spectrum, general HAT inhibitors such as CPTH2 and CPTH6 can interfere with the acetylation activity of Esa1. Lastly, compounds like NU9056 and TH1834, known to target mammalian counterparts or closely related MYST proteins, can also be expected to exhibit inhibitory effects on Esa1.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Garcinol | 78824-30-3 | sc-200891 sc-200891A | 10 mg 50 mg | $136.00 $492.00 | 13 | |
Known HAT inhibitor that can directly inhibit Esa1 by preventing its acetylation activity. | ||||||
Anacardic Acid | 16611-84-0 | sc-202463 sc-202463A | 5 mg 25 mg | $100.00 $200.00 | 13 | |
HAT inhibitor that can inhibit Esa1 by binding to its acetyl-CoA binding site. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Can inhibit Esa1 by disrupting its interaction with acetyl-CoA. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Can inhibit the enzymatic activity of Esa1 due to its direct interaction. | ||||||
Butyrolactone 3 | 778649-18-6 | sc-358657 sc-358657A sc-358657B | 5 mg 50 mg 100 mg | $215.00 $1438.00 $2764.00 | 3 | |
A synthetic compound known to inhibit MYST family of HATs including Esa1. | ||||||
Salermide | 1105698-15-4 | sc-224276 sc-224276A | 5 mg 10 mg | $70.00 $105.00 | 3 | |
Inhibits sirtuins but may also affect HATs indirectly, including Esa1. | ||||||
CPTH2 | 357649-93-5 | sc-255032 | 5 mg | $160.00 | 1 | |
A general HAT inhibitor that can interfere with Esa1's acetylation activity. | ||||||
NU 9056 | 1450644-28-6 | sc-397052 | 10 mg | $189.00 | 2 | |
Known to target Tip60, a mammalian counterpart of Esa1, and can inhibit its activity. | ||||||