Molecular structure of NU 9056, CAS Number: 1450644-28-6
NU 9056 (CAS 1450644-28-6)
See product citations (2)
Alternate Names:
5-(1,2-Thiazol-5-yldisulfanyl)-1,2-thiazole
Application:
NU 9056 is a selective KAT5 histone acetyltransferase inhibitor
CAS Number:
1450644-28-6
Molecular Weight:
232.37
Molecular Formula:
C6H4N2S4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
NU 9056 is a selective cPLA2 (KAT5) histone acetyltransferase inhibitor. It may act to inhibit acetylation of proteins in prostate cancer cell lines. It blocks the DNA damage response, decreases proliferation of LNCap cells, and induces apoptosis by caspase activation. In vitro studies have shown that NU 9056 has anti-cancer, anti-inflammatory, and anti-fungal activity. Additionally, NU 9056 may act to inhibit the enzyme cyclooxygenase-2 (COX-2), which is involved in the production of prostaglandins.
NU 9056 (CAS 1450644-28-6) References
- Characterisation of a Tip60 specific inhibitor, NU9056, in prostate cancer. | Coffey, K., et al. 2012. PLoS One. 7: e45539. PMID: 23056207
- Epigenetic Regulation of Cytosolic Phospholipase A2 in SH-SY5Y Human Neuroblastoma Cells. | Tan, CS., et al. 2016. Mol Neurobiol. 53: 3854-3872. PMID: 26162318
- Clinacanthus nutans Extracts Modulate Epigenetic Link to Cytosolic Phospholipase A2 Expression in SH-SY5Y Cells and Primary Cortical Neurons. | Tan, CS., et al. 2016. Neuromolecular Med. 18: 441-52. PMID: 27319010
- Novel detection of post-translational modifications in human monocyte-derived dendritic cells after chronic alcohol exposure: Role of inflammation regulator H4K12ac. | Parira, T., et al. 2017. Sci Rep. 7: 11236. PMID: 28894190
- Inhibition of Tip60 Reduces Lytic and Latent Gene Expression of Kaposi's Sarcoma-Associated Herpes Virus (KSHV) and Proliferation of KSHV-Infected Tumor Cells. | Simpson, S., et al. 2018. Front Microbiol. 9: 788. PMID: 29740418
- PRMT5-mediated regulation of developmental myelination. | Scaglione, A., et al. 2018. Nat Commun. 9: 2840. PMID: 30026560
- Blocking H2A.Z Incorporation via Tip60 Inhibition Promotes Systems Consolidation of Fear Memory in Mice. | Narkaj, K., et al. 2018. eNeuro. 5: PMID: 30417078
- Histone acetyltransferase inhibition rescues differentiation of emerin-deficient myogenic progenitors. | Bossone, KA., et al. 2020. Muscle Nerve. 62: 128-136. PMID: 32304242
- Digging Deeper into Breast Cancer Epigenetics: Insights from Chemical Inhibition of Histone Acetyltransferase TIP60 In Vitro. | Idrissou, M., et al. 2020. OMICS. 24: 581-591. PMID: 32960142
- Inhibition of PfMYST Histone Acetyltransferase Activity Blocks Plasmodium falciparum Growth and Survival. | Sen, U., et al. 2020. Antimicrob Agents Chemother. 65: PMID: 33046499
- NU9056, a KAT 5 Inhibitor, Treatment Alleviates Brain Dysfunction by Inhibiting NLRP3 Inflammasome Activation, Affecting Gut Microbiota, and Derived Metabolites in LPS-Treated Mice. | Chen, L., et al. 2021. Front Nutr. 8: 701760. PMID: 34327209
- The Acetyltransferase KAT5 Inhibitor NU 9056 Promotes Apoptosis and Inhibits JAK2/STAT3 Pathway in Extranodal NK/T Cell Lymphoma. | Xu, L., et al. 2022. Anticancer Agents Med Chem. 22: 1530-1540. PMID: 34503423
- The Protective Effects of KAT5 Inhibition on Ocular Inflammation by Mediating the PI3K/AKT Pathway in a Murine Model of Allergic Conjunctivitis. | Luo, F., et al. 2022. Invest Ophthalmol Vis Sci. 63: 4. PMID: 35503228
Inhibitor of:
CILP-2, cPLA2, Esa1, MOZ, TADA2B, and TIP60.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NU 9056, 10 mg | sc-397052 | 10 mg | $189.00 | |||
| US: Only available in the US | ||||||