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epsin 3 Inhibitors

EPSIN3 is an intrinsic component of the endocytic machinery, a system responsible for the internalization of a vast array of molecules from the extracellular environment into the cellular matrix. This protein is vital for processes requiring the selective uptake of specific molecules, which is achieved through specialized vesicular structures. As a component of the clathrin-mediated endocytosis pathway, EPSIN3 interacts with phospholipids present in the plasma membrane and assists in vesicle formation and cargo selection. Such processes are paramount for maintaining cellular homeostasis, ensuring correct signaling cascades, and keeping the balance of cellular membrane components. Without the proper functioning of proteins like EPSIN3, cells would struggle to regulate their internal environment, leading to disruptions in signaling and transport. Inhibitors targeting EPSIN3 are diverse compounds that modulate the protein's function either directly or indirectly. These inhibitors generally function to disrupt the interaction of EPSIN3 with its binding partners, or they alter the surrounding cellular environment, rendering EPSIN3 less effective or even inactive. While the precise mechanisms of action may vary, the overarching goal is to impede the endocytic process by hampering the formation or maturation of vesicles. By doing so, the intracellular trafficking of molecules is affected, leading to alterations in cellular signaling and transport dynamics. Many of these inhibitors target the pathways or processes EPSIN3 is involved in, rather than the protein directly, offering a broad strategy to modulate its function. Their impact underscores the intricate interplay of various proteins and pathways within the cellular milieu and emphasizes the delicate balance required for maintaining cellular equilibrium. The exploration of these inhibitors not only provides insights into the fundamental processes of cell biology but also underscores the potential to harness this knowledge for various applications.

Items 1 to 10 of 12 total

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Product Name	CAS #	Catalog #	QUANTITY	Price	Citations	RATING
Dynamin Inhibitor I, Dynasore	304448-55-3	sc-202592	10 mg	$89.00	44	(2)
Dynasore acts as a non-competitive inhibitor of dynamin's GTPase activity, pivotal for vesicle scission during endocytosis. Its modulatory activity could plausibly attenuate EPSIN3 function via inhibition of vesicular maturation and scission events.
Pitstop 2	1419320-73-2	sc-507418	10 mg	$360.00		(0)
Pitstop 2 impedes clathrin-mediated endocytosis by targeting the terminal domain of clathrin and adaptor protein 2 (AP2). The inhibitor could exert an indirect effect on EPSIN3 by modulating the clathrin lattice assembly process.
Chlorpromazine	50-53-3	sc-357313 sc-357313A	5 g 25 g	$61.00 $110.00	21	(1)
Chlorpromazine, by perturbing clathrin lattices at the plasma membrane, obstructs clathrin-mediated endocytosis. Its potential impact on EPSIN3 may be a downstream effect due to the disruption of the endocytic machinery.
Dansylcadaverine	10121-91-2	sc-214851 sc-214851A sc-214851B	100 mg 250 mg 1 g	$52.00 $89.00 $240.00	4	(1)
This compound serves as a dual inhibitor, targeting transglutaminase and impeding clathrin-mediated endocytosis, potentially modulating EPSIN3's role in vesicle biogenesis.
Genistein	446-72-0	sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F	100 mg 500 mg 1 g 5 g 10 g 25 g 100 g	$45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00	46	(1)
As a tyrosine kinase inhibitor, Genistein obstructs caveolin-dependent endocytosis. Though its primary mechanism targets caveolae, there exists the potential for a broader modulation of endocytic pathways, including those involving EPSIN3.
Nystatin	1400-61-9	sc-212431 sc-212431A sc-212431B sc-212431C	5 MU 25 MU 250 MU 5000 MU	$51.00 $129.00 $251.00 $3570.00	7	(1)
By selectively binding to cholesterol, Nystatin disrupts lipid raft integrity. While primarily known for caveolae-mediated endocytosis inhibition, potential collateral effects on EPSIN3-mediated processes cannot be ruled out.
Methyl-β-cyclodextrin	128446-36-6	sc-215379A sc-215379 sc-215379C sc-215379B	100 mg 1 g 10 g 5 g	$20.00 $48.00 $160.00 $82.00	19	(1)
This cholesterol-depleting agent disrupts the organization of lipid raft domains, which might lead to perturbations in various endocytosis pathways, potentially influencing EPSIN3's role.
Wortmannin	19545-26-7	sc-3505 sc-3505A sc-3505B	1 mg 5 mg 20 mg	$67.00 $223.00 $425.00	97	(3)
Wortmannin, a potent phosphoinositide 3-kinases (PI3Ks) inhibitor, can induce alterations in endocytic pathways via modulation of PI(4,5)P2 levels, potentially eliciting an indirect effect on EPSIN3 functionality.
LY 294002	154447-36-6	sc-201426 sc-201426A	5 mg 25 mg	$123.00 $400.00	148	(1)
Similar to Wortmannin, LY294002 inhibits PI3K, consequently perturbing endocytic trajectories. Its downstream influence on EPSIN3, though indirect, stems from the alteration in phosphoinositide dynamics.
Latrunculin A, Latrunculia magnifica	76343-93-6	sc-202691 sc-202691B	100 µg 500 µg	$265.00 $815.00	36	(2)
By sequestering actin monomers, Latrunculin A precludes actin polymerization. Given the intricate interplay between actin dynamics and endocytosis, such modulation might indirectly impinge upon EPSIN3's role.

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epsin 3 Inhibitors

Dynamin Inhibitor I, Dynasore

Pitstop 2

Chlorpromazine

Dansylcadaverine

Genistein

Nystatin

Methyl-β-cyclodextrin

Wortmannin

LY 294002

Latrunculin A, Latrunculia magnifica