EPB41L5 Inhibitors
EPB41L5, also known as erythrocyte membrane protein band 4.1-like 5, is a member of the band 4.1 superfamily of proteins and is primarily expressed in epithelial cells, where it plays crucial roles in cell-cell adhesion, cytoskeletal organization, and signal transduction. The function of EPB41L5 is multifaceted, as it interacts with various cytoskeletal and membrane proteins to regulate cellular morphology, polarity, and signaling pathways. One of the key functions of EPB41L5 is its involvement in the assembly and maintenance of epithelial cell junctions, including adherens junctions and tight junctions, which are essential for tissue integrity and barrier function. Additionally, EPB41L5 participates in the regulation of cell migration, polarity, and proliferation, highlighting its importance in epithelial tissue development and homeostasis.
Inhibiting EPB41L5 activity poses a significant challenge due to its diverse functions and essential role in cellular processes. However, strategies for inhibiting EPB41L5 could involve disrupting its interactions with binding partners or interfering with its structural and functional integrity. Targeting protein-protein interactions involving EPB41L5, such as its association with cytoskeletal proteins or junctional complexes, may prevent its localization to specific subcellular compartments or disrupt its ability to regulate cellular processes. Additionally, modulating post-translational modifications or proteolytic processing of EPB41L5 may affect its stability, activity, or interactions with other proteins, thereby inhibiting its function in epithelial cells. Understanding the precise mechanisms underlying EPB41L5 inhibition will provide valuable insights into its physiological roles and implications in epithelial biology and disease states.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel, a microtubule-stabilizing agent, indirectly inhibits EPB41L5 by disrupting the dynamic instability of microtubules. EPB41L5 facilitates cell adhesion and migration by interacting with the actin cytoskeleton, which is dependent on the microtubule network. Therefore, Paclitaxel can indirectly inhibit EPB41L5 function by stabilizing microtubules. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Cytochalasin D is a potent inhibitor of actin filament polymerization. Since EPB41L5 is involved in actin cytoskeleton reorganization, the disruption of actin filaments by Cytochalasin D can lead to the functional inhibition of EPB41L5. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Latrunculin A sequesters actin monomers and prevents their incorporation into actin filaments. As EPB41L5 plays a role in cytoskeletal reorganization, the inhibition of actin polymerization by Latrunculin A can indirectly inhibit EPB41L5 activity. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Jasplakinolide promotes actin polymerization and stabilizes actin filaments. By altering the dynamics of the actin cytoskeleton, Jasplakinolide can indirectly inhibit the function of EPB41L5, which is involved in the reorganization of the actin cytoskeleton. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $183.00 $313.00 $464.00 $942.00 $1723.00 | 7 | |
Blebbistatin is a specific inhibitor of myosin II ATPase activity. Since myosin II is crucial for cell motility and the reorganization of the actin cytoskeleton, the inhibition of myosin II by Blebbistatin can indirectly inhibit EPB41L5 function. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubule dynamics by binding to β-tubulin and preventing its polymerization. Given that EPB41L5 function depends on a functional cytoskeleton, Nocodazole can indirectly inhibit EPB41L5 by disrupting microtubule dynamics. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Vinblastine binds to tubulin dimers, inhibiting assembly of microtubule structures. Disruption of these structures can indirectly inhibit EPB41L5, which interacts with the cytoskeleton. | ||||||
Wiskostatin | 253449-04-6 | sc-204399 sc-204399A sc-204399B sc-204399C | 1 mg 5 mg 25 mg 50 mg | $49.00 $124.00 $441.00 $828.00 | 4 | |
Wiskostatin inhibits the N-WASP-Arp2/3 pathway, crucial in actin nucleation and branching. As EPB41L5 is involved in cytoskeletal reorganization, Wiskostatin can indirectly inhibit its function by affecting actin dynamics. | ||||||
Eribulin | 253128-41-5 | sc-507547 | 5 mg | $865.00 | ||
Eribulin is a microtubule dynamics inhibitor that binds to specific sites on tubulin, inhibiting its polymerization into microtubules. This can indirectly inhibit EPB41L5 by affecting cytoskeletal organization. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 inhibits ROCK, a serine/threonine kinase involved in actin cytoskeleton organization. By inhibiting ROCK, Y-27632 indirectly affects the function of EPB41L5, which interacts with the cytoskeleton. | ||||||