Date published: 2025-9-5

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EP1 Activators

EP1 activators represent a specialized category of chemicals that influence the biological activity of the EP1 receptor, a member of the prostaglandin E2 (PGE2) receptor subfamily. Typically, these activators possess functional groups or structural elements that enable them to bind effectively to the EP1 receptor, a feature critical to their mode of action. This binding is highly specific and can occur with varying degrees of affinity, which directly impacts the intensity and duration of the activator's effects on the receptor. Sulprostone, a synthetic prostaglandin E2 (PGE2) analog, exemplifies a direct activator of EP1. It binds to the EP1 receptor, contributing to its role in smooth muscle contraction and inflammatory responses. Similarly, Butaprost, another synthetic PGE2 analog, directly activates EP1, affecting various physiological processes. These EP1 activators mimic the actions of endogenous prostaglandins, serving as ligands that specifically target the EP1 receptor. The synthetic analogs, like 17-phenyl trinor PGE2 and ONO-8713, further highlight the versatility in designing compounds to interact with EP1. The interaction of EP1 activators with the EP1 receptor initiates a cascade of cellular responses, which depend on the receptor's distribution and the cell type in which it is expressed. Upon activation, these receptors can influence a range of cellular processes. The specificity of this interaction is a key aspect of the functional role of EP1 activators, as it determines the consequent cellular responses. It's important to note that while these activators share the commonality of targeting the EP1 receptor, the outcomes of their activation can vary significantly. This variation is attributed to differences in their chemical structure, which can lead to distinct conformational changes in the receptor upon binding. These changes in the receptor's structure then translate into varied cellular responses. As a result, the study and understanding of EP1 activators are crucial in elucidating the complex dynamics of EP1 receptor-mediated signaling pathways and their implications in various biological contexts.

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Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

17-Phenyl-trinor-prostaglandin E2

38315-43-4sc-201255
sc-201255A
1 mg
10 mg
$73.00
$587.00
5
(1)

17-Phenyl-trinor-prostaglandin E2 is a synthetic analogue of prostaglandin E2. It specifically activates the EP1 receptor, a subtype of prostaglandin receptors. Through this activation, it influences various biological processes related to the functioning of the EP1 receptor, which is known to play a role in mediating physiological responses to prostaglandin E2.

Misoprostol

59122-46-2sc-201264
sc-201264A
sc-201264B
10 mg
100 mg
1 g
$179.00
$1126.00
$6941.00
2
(1)

Misoprostol is a synthetic compound that functions as an agonist at various prostaglandin receptors, including EP1. Its activation of the EP1 receptor influences biological pathways associated with prostaglandin E2 signaling, affecting a range of physiological processes through its interaction with these receptors.

Sulprostone

60325-46-4sc-201348
sc-201348A
1 mg
5 mg
$206.00
$592.00
8
(1)

Sulprostone is a chemical n for its role as an EP1 receptor activator. It engages with the EP1 receptor, which is one of the subtypes of prostaglandin receptors. This interaction facilitates various biological processes linked to prostaglandin E2 signaling, influencing physiological responses in the body related to the activity of these receptors.

Latanoprost

130209-82-4sc-201354
sc-201354A
sc-201354A-CW
1 mg
5 mg
5 mg
$58.00
$230.00
$306.00
2
(1)

Latanoprost is a chemical that acts as an agonist of the EP1 receptor, a specific prostaglandin receptor subtype. This interaction is known to mediate various physiological processes through the prostaglandin signaling pathways, influencing the activity and responses related to prostaglandin E2 receptors.

19(R)-hydroxy Prostaglandin E1

64625-55-4sc-205069
sc-205069A
50 µg
100 µg
$90.00
$172.00
(0)

19(R)-hydroxy Prostaglandin E1is a chemical that acts as an activator of the EP1 receptor, a specific subtype of prostaglandin receptors. Its interaction with EP1 receptors influences various biological processes through prostaglandin E2 signaling pathways, playing a role in physiological responses associated with these receptor activities.

SC 19220

19395-87-0sc-203450B
sc-203450C
sc-203450
sc-203450A
1 mg
5 mg
10 mg
50 mg
$22.00
$104.00
$184.00
$797.00
2
(0)

SC-19220 is a selective EP1 receptor antagonist rather than an activator. Therefore, it is not included in the subsequent description of EP1 activators.

Butaprost

69685-22-9sc-221387
sc-221387A
500 µg
1 mg
$124.00
$237.00
1
(0)

A selective EP2 receptor agonist, but its action within the prostaglandin system might have secondary effects on EP1 expression.

PGE1 (Prostaglandin E1)

745-65-3sc-201223
sc-201223A
1 mg
10 mg
$30.00
$142.00
16
(4)

Prostaglandin E1 (PGE1) is an endogenous prostaglandin that can directly activate EP1. It binds to the EP1 receptor, initiating downstream signaling events. PGE1's activation of EP1 is part of its broader role in various physiological processes, including vasodilation and inhibition of platelet aggregation. PGE1's direct interaction with EP1 highlights its specific role as an endogenous activator of this prostaglandin receptor.

PGE2

363-24-6sc-201225
sc-201225C
sc-201225A
sc-201225B
1 mg
5 mg
10 mg
50 mg
$56.00
$156.00
$270.00
$665.00
37
(1)

16,16-Dimethyl PGE2 is a synthetic analog of prostaglandin E2 (PGE2) that can directly activate EP1. It binds to the EP1 receptor, initiating downstream signaling events. This compound's ability to mimic the action of endogenous prostaglandins highlights its role as a chemical activator of EP1, influencing cellular responses associated with prostaglandin signaling pathways.

Carboprost Tromethanimine

58551-69-2sc-504637
1 mg
$300.00
(0)

This synthetic analog of prostaglandin F2α may alter EP1 expression by modulating the overall prostaglandin receptor dynamics.