ELOVL5 Activators
ELOVL5 Activators primarily function by providing substrates for elongation or creating a cellular environment conducive to ELOVL5's activity. Substrates such as Palmitic Acid, Stearic Acid, Oleic Acid, EPA, Docosa-4Z,7Z,10Z,13Z,16Z,19Z-hexaenoic Acid (22:6, n-3), Arachidonic Acid (20:4, n-6), Linoleic Acid, and α-Linolenic Acid are crucial for ELOVL5's elongation of long-chain fatty acids. The presence of these substrates directly enhances ELOVL5's functional activity by ensuring a continuous supply of necessary molecules for the elongation process. For example, EPA and DHA, being polyunsaturated fatty acids, are pivotal in the synthesis of longer chain polyunsaturated fatty acids by ELOVL5, a process essential for cell membrane integrity and signaling. Similarly, monounsaturated and saturated fatty acids like Oleic Acid and Stearic Acid are vital in the synthesis of diverse long-chain fatty acids, underscoring ELOVL5's role in lipid homeostasis and cellular health.
In addition to substrate provision, compounds like Cerulenin (synthetic), Triacsin C Solution in DMSO, 4-Phenylbutyric acid, and Tunicamycin enhance ELOVL5 activity indirectly. Cerulenin (synthetic) inhibits fatty acid synthesis pathways, reducing competition and thus channeling more substrates towards ELOVL5. Triacsin C Solution in DMSO, by inhibiting ACSL, increases the availability of long-chain fatty acids for ELOVL5, augmenting its elongation process. 4-Phenylbutyric acid aids in reducing endoplasmic reticulum stress, potentially improving the functional environment for ELOVL5, thereby facilitating more efficient fatty acid elongation. Tunicamycin's role in inducing stress responses might indirectly upregulate fatty acid synthesis pathways, including those mediated by ELOVL5. These mechanisms collectively ensure an optimal supply and environment for ELOVL5, enhancing its vital role in fatty acid elongation and overall cellular lipid balance.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Palmitic Acid | 57-10-3 | sc-203175 sc-203175A | 25 g 100 g | $114.00 $286.00 | 2 | |
Palmitic Acid is a substrate for ELOVL5 in the synthesis of long-chain fatty acids. By providing substrate availability, Palmitic Acid enhances the elongation activity of ELOVL5, facilitating the production of longer chain fatty acids. | ||||||
Stearic Acid | 57-11-4 | sc-203408 sc-203408A sc-203408B | 100 g 1 kg 5 kg | $26.00 $32.00 $117.00 | 1 | |
Stearic Acid serves as a substrate for ELOVL5. The presence of Stearic Acid enables ELOVL5 to catalyze the elongation process, leading to the synthesis of even longer chain fatty acids. | ||||||
Oleic Acid | 112-80-1 | sc-200797C sc-200797 sc-200797A sc-200797B | 1 g 10 g 100 g 250 g | $37.00 $104.00 $580.00 $1196.00 | 10 | |
Oleic Acid, a monounsaturated fatty acid, can be elongated by ELOVL5. Its availability ensures ELOVL5 activity in elongating monounsaturated fatty acids, crucial for maintaining cellular lipid balance. | ||||||
Docosa-4Z,7Z,10Z,13Z,16Z,19Z-hexaenoic Acid (22:6, n-3) | 6217-54-5 | sc-200768 sc-200768A sc-200768B sc-200768C sc-200768D | 100 mg 1 g 10 g 50 g 100 g | $94.00 $210.00 $1779.00 $8021.00 $16657.00 | 11 | |
Docosa-4Z,7Z,10Z,13Z,16Z,19Z-hexaenoic Acid (22:6, n-3) acts as a substrate for ELOVL5 in the biosynthesis of very long-chain polyunsaturated fatty acids. By providing DHA, ELOVL5's activity in producing essential fatty acids for cell membrane integrity and signaling is enhanced. | ||||||
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $92.00 $240.00 $4328.00 | 9 | |
Arachidonic Acid (20:4, n-6) can be elongated by ELOVL5, playing a role in the synthesis of longer chain polyunsaturated fatty acids. This elongation process is crucial for maintaining cellular lipid homeostasis. | ||||||
Linoleic Acid | 60-33-3 | sc-200788 sc-200788A sc-200788B sc-200788C | 100 mg 1 g 5 g 25 g | $34.00 $64.00 $166.00 $281.00 | 4 | |
Linoleic Acid serves as a substrate for ELOVL5, facilitating the synthesis of longer chain polyunsaturated fatty acids, which are essential components of cell membranes and signaling molecules. | ||||||
α-Linolenic Acid | 463-40-1 | sc-205545 sc-205545A | 50 mg 250 mg | $38.00 $115.00 | 2 | |
α-Linolenic Acid is elongated by ELOVL5, contributing to the production of essential fatty acids, vital for various cellular functions and membrane structures. | ||||||
Triacsin C Solution in DMSO | 76896-80-5 | sc-200574 sc-200574A | 100 µg 1 mg | $187.00 $843.00 | 14 | |
Triacsin C Solution in DMSO inhibits ACSL, leading to an increased availability of long-chain fatty acids as substrates for ELOVL5, enhancing its elongation activity. | ||||||
4-Phenylbutyric acid | 1821-12-1 | sc-232961 sc-232961A sc-232961B | 25 g 100 g 500 g | $53.00 $136.00 $418.00 | 10 | |
4-Phenylbutyric acid, known for its role in reducing endoplasmic reticulum stress, may facilitate the functional environment for ELOVL5, enhancing its activity in fatty acid elongation. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Tunicamycin, by inhibiting N-linked glycosylation, can lead to stress responses that may indirectly upregulate fatty acid synthesis pathways, including ELOVL5-mediated elongation of fatty acids. | ||||||