ELOF1 Inhibitors
ELOF1 inhibitors encompass a variety of compounds that influence DNA repair pathways and cellular responses to DNA damage where ELOF1 is functionally active. Compounds such as Veliparib, Olaparib, and ABT-888 are PARP inhibitors that compromise the PARP-dependent DNA repair mechanisms. Given ELOF1's role in DNA damage response and repair, the inhibition of PARP is expected to undermine the efficiency of ELOF1-facilitated repair processes. This can lead to an accumulation of DNA lesions, which ELOF1 would normally help to resolve, thereby impairing the functional activity of ELOF1.
Other compounds, such as NU7441, KU-55933, and NU7026, target the kinases DNA-PK, ATM, and ATR, which are pivotal in signaling and orchestrating the cellular response to DNA damage. By inhibiting these kinases, the compounds can disrupt the recruitment and action of ELOF1 at DNA damage sites, thereby indirectly leading to reduced efficacy of ELOF1 in the repair process. Mirin's inhibition of the MRN complex and MK-1775's targeting of WEE1 similarly create conditions that are less favorable for ELOF1's activity. These inhibitors collectively contribute to a cellular environment where the pathways that ELOF1 relies on for proper function are attenuated, leading to a decrease in its activity. CGK733 and Caffeine provide broader inhibition of ATM and ATR, indicating that a wide spectrum of kinase activity reduction can influence ELOF1's role in the DNA damage response.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Veliparib | 912444-00-9 | sc-394457A sc-394457 sc-394457B | 5 mg 10 mg 50 mg | $182.00 $275.00 $726.00 | 3 | |
Veliparib is a PARP inhibitor that interferes with DNA repair mechanisms. ELOF1 is involved in DNA damage response; inhibition of PARP by veliparib impairs the repair process, potentially diminishing ELOF1's role in facilitating DNA repair fidelity. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $210.00 $305.00 $495.00 | 10 | |
Olaparib, another PARP inhibitor, similarly disrupts DNA repair pathways. Its inhibition of PARP can compromise ELOF1's function by reducing the efficiency of DNA repair, where ELOF1 is engaged in lesion bypass and repair processes. | ||||||
NU 7441 | 503468-95-9 | sc-208107 | 5 mg | $357.00 | 10 | |
NU7441 is a DNA-PK inhibitor which is essential for DNA double-strand break repair. ELOF1 operates in conjunction with the DNA damage response; inhibition of DNA-PK by NU7441 can thus attenuate the recruitment or activity of ELOF1 at damage sites. | ||||||
ATM Kinase Inhibitor | 587871-26-9 | sc-202963 | 2 mg | $110.00 | 28 | |
KU-55933 acts as an ATM inhibitor, downregulating DNA damage checkpoint signaling. ELOF1's involvement in DNA repair means ATM inhibition could reduce its recruitment to damage sites, indirectly impairing ELOF1's functional role in repair. | ||||||
AZD7762 | 860352-01-8 | sc-364423 | 2 mg | $107.00 | ||
AZD7762 is a CHK1/2 inhibitor that affects cell cycle checkpoints during DNA damage response. As ELOF1 is implicated in the processing of DNA lesions, CHK1/2 inhibition could decrease ELOF1-mediated repair activities. | ||||||
ABT-888 | 912445-05-7 | sc-202901 sc-202901A sc-202901B | 1 mg 5 mg 25 mg | $117.00 $173.00 $510.00 | 24 | |
ABT-888, also known as veliparib, is a PARP inhibitor, functioning similarly to other PARP inhibitors, thereby impairing DNA repair and possibly ELOF1's associated repair mechanisms. | ||||||
PARP Inhibitor VIII, PJ34 | 344458-15-7 | sc-204161 sc-204161A | 1 mg 5 mg | $58.00 $142.00 | 20 | |
PJ-34 is a potent PARP inhibitor, which by reducing PARP activity, can impede the DNA damage response and repair in which ELOF1 is a participant, potentially leading to reduced ELOF1 function. | ||||||
DNA-PK Inhibitor II | 154447-35-5 | sc-202143 sc-202143A | 10 mg 50 mg | $155.00 $660.00 | 6 | |
NU7026 is a DNA-PK inhibitor, thereby hindering the repair of DNA double-strand breaks. This could lead to a diminished role of ELOF1 in DNA repair due to its association with DNA-PK in the damage response. | ||||||
ATM/ATR Kinase Inhibitor Inhibitor | 905973-89-9 | sc-202964 | 5 mg | $106.00 | 8 | |
CGK733 is an inhibitor of ATM and ATR, impeding the response to DNA damage. This may indirectly lessen ELOF1 activity by reducing the cellular signaling necessary for its recruitment and function in repair. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine is known to nonspecifically inhibit ATM and ATR kinase activities. Through this broad inhibition, it can suppress the damage response pathways that are crucial for ELOF1-dependent repair processes. | ||||||