Molecular structure of PARP Inhibitor VIII, PJ34, CAS Number: 344458-15-7
PARP Inhibitor VIII, PJ34 (CAS 344458-15-7)
See product citations (20)
Alternate Names:
PJ-34; 2-(Dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide hydrochloride
Application:
PARP Inhibitor VIII, PJ34 is a potent and cell-permeable inhibitor of PARP
CAS Number:
344458-15-7
Purity:
≥98%
Molecular Weight:
331.80
Molecular Formula:
C17H17N3O2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
PARP Inhibitor VIII, PJ34 is a cell-permeable, water-soluble phenanthridinone derivative which inhibits of poly(ADP-ribose) polymerase (PARP EC50 = 20 nM). It is believed to be up to 10,000 times more potent than 3-aminobenzamide (sc-3501) which has an EC = 200 muM. PARP over-activation can lead to NAD depletion and consequent necrosis, thus inducing inflammatory conditions. It has been observed that at lower concentrations, PARP Inhibitor VIII, PJ34 displays antioxidant activity. Studies conducted in vitro on stroke models indicate that this compound has neuroprotective functions. PARP Inhibitor VIII, PJ34 is an inhibitor of PARP-1 and PARP-2.
PARP Inhibitor VIII, PJ34 (CAS 344458-15-7) References
- PJ34, a poly-ADP-ribose polymerase inhibitor, modulates renal injury after thoracic aortic ischemia/reperfusion. | Stone, DH., et al. 2005. Surgery. 138: 368-74. PMID: 16153449
- PJ34, an inhibitor of PARP-1, suppresses cell growth and enhances the suppressive effects of cisplatin in liver cancer cells. | Huang, SH., et al. 2008. Oncol Rep. 20: 567-72. PMID: 18695907
- PJ34, a poly-ADP-ribose polymerase inhibitor, modulates visceral mitochondrial activity and CD14 expression following thoracic aortic ischemia-reperfusion. | Stone, DH., et al. 2009. Am J Surg. 198: 250-5. PMID: 19268911
- PJ34, a poly(ADP-ribose) polymerase (PARP) inhibitor, reverses melphalan-resistance and inhibits repair of DNA double-strand breaks by targeting the FA/BRCA pathway in multidrug resistant multiple myeloma cell line RPMI8226/R. | Xiong, T., et al. 2015. Int J Oncol. 46: 223-32. PMID: 25351371
- Intervention timing and effect of PJ34 on astrocytes during oxygen-glucose deprivation/reperfusion and cell death pathways. | Cai, C., et al. 2015. J Huazhong Univ Sci Technolog Med Sci. 35: 397-404. PMID: 26072080
- Synergistic suppressive effect of PARP-1 inhibitor PJ34 and HDAC inhibitor SAHA on proliferation of liver cancer cells. | Liang, BY., et al. 2015. J Huazhong Univ Sci Technolog Med Sci. 35: 535-540. PMID: 26223923
- PJ34, a PARP1 inhibitor, promotes endothelial repair in a rabbit model of high fat diet-induced atherosclerosis. | Zha, S., et al. 2019. Cell Cycle. 18: 2099-2109. PMID: 31276434
- The phenanthrene derivative PJ34 exclusively eradicates human pancreatic cancer cells in xenografts. | Visochek, L., et al. 2019. Oncotarget. 10: 6269-6282. PMID: 31692907
- PJ34 Protects Photoreceptors from Cell Death by Inhibiting PARP-1 Induced Parthanatos after Experimental Retinal Detachment. | Dong, K., et al. 2021. Curr Eye Res. 46: 115-121. PMID: 32478624
- PJ34, a PARP1 inhibitor, attenuates acute allograft rejection after murine heart transplantation via regulating the CD4+ T lymphocyte response. | Chen, X., et al. 2021. Transpl Int. 34: 561-571. PMID: 33368686
- Poly(ADP-Ribose) Polymerase Inhibitor PJ34 Reduces Brain Damage after Stroke in the Neonatal Mouse Brain. | Bonnin, P., et al. 2021. Curr Issues Mol Biol. 43: 301-312. PMID: 34200155
- PARP inhibitor PJ34 ameliorates cognitive impairments induced by transient cerebral ischemia/reperfusion through its anti-inflammatory effects in a rat model. | Jiao, Y. and Li, G. 2021. Neurosci Lett. 764: 136202. PMID: 34478817
- Poly(ADP-ribose) polymerase inhibitor PJ34 protects against UVA-induced oxidative damage in corneal endothelium. | Wang, X., et al. 2021. Apoptosis. 26: 600-611. PMID: 34581992
Inhibitor of:
4930547N16Rik, ACSL, ACSL4, ART2B, C12orf32, ELOF1, hPMS1, Like-Sm (LSm), PARP S, PARP-1, PARP-11, PARP-12, PARP-14, PARP-16, PARP-2, PARP-4, PARP-6, PARP-8, PARP-9, PBK, RAD54L2, Rad57, Ribosomal Protein L22, Ribosome (RPL; 40S; 60S), RMI2, RNF146, and RTEL1.Activator of:
4930547N16Rik, ARH3, F730047E07Rik, I-SceI, PARG, PARP-7, RAD51AP2, and SMYD3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PARP Inhibitor VIII, PJ34, 1 mg | sc-204161 | 1 mg | $57.00 | |||
PARP Inhibitor VIII, PJ34, 5 mg | sc-204161A | 5 mg | $139.00 |