EG668526 Activators
Secretoglobin, family 2B, member 17 (SCGB2B17) activators are a class of chemicals that can enhance the activity of SCGB2B17 through various biochemical and cellular pathways. The action of these compounds is not direct; rather, they influence the regulatory mechanisms that control the expression or activity of SCGB2B17. Estradiol and Beta-estradiol, by engaging with estrogen receptors, can induce transcriptional changes that lead to the upregulation of secretoglobins. Progesterone and Pregnenolone operate through similar steroid hormone pathways, influencing secretoglobin activity by modulating the expression of their encoding genes. Dexamethasone and Cortisol, both glucocorticoids, exert their effect through glucocorticoid receptors, which can activate secretoglobin gene expression, including SCGB2B17.
Forskolin and IBMXwork through the cAMP signaling pathway, with Forskolin directly activating adenylate cyclase to increase cAMP levels, thereby activating PKA, which could phosphorylate transcription factors involved in secretoglobin gene expression. IBMX, by inhibiting the degradation of cAMP, prolongs PKA activation and thereby may enhance SCGB2B17 activity. Retinoic Acid and Vitamin D3, through their respective receptors, affect gene expression directly by binding to DNA response elements, which may include those controlling the expression of SCGB2B17. Lithium is known to enhance the Wnt signaling pathway, whose downstream effects on gene transcription could potentially upregulate secretoglobin expression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
Estradiol, a primary estrogen steroid hormone, can enhance secretoglobin activity by binding to estrogen receptors which may be associated with the regulatory regions of genes encoding secretoglobins, leading to increased expression and activity of secretoglobin proteins such as SCGB2B17. | ||||||
Progesterone | 57-83-0 | sc-296138A sc-296138 sc-296138B | 1 g 5 g 50 g | $20.00 $51.00 $292.00 | 3 | |
Progesterone, a steroid hormone, can lead to the functional activation of secretoglobin proteins by interacting with progesterone receptors which may upregulate secretoglobin genes, possibly including SCGB2B17. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
A synthetic glucocorticoid, dexamethasone, can affect the activity of secretoglobin proteins by activating glucocorticoid receptors, which may then bind to glucocorticoid response elements on genes encoding secretoglobins, potentially increasing SCGB2B17 activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
3-Isobutyl-1-methylxanthine (IBMX) is a non-specific inhibitor of phosphodiesterases, increasing cAMP by preventing its degradation, which could enhance the activity of secretoglobin proteins through cAMP-dependent pathways likely to influence SCGB2B17. | ||||||
Pregnenolone | 145-13-1 | sc-204860 sc-204860A sc-204860B sc-204860C | 5 g 25 g 100 g 500 g | $85.00 $145.00 $340.00 $1100.00 | ||
Pregnenolone is a neurosteroid that, through its metabolites, can enhance secretoglobin activity by potentially modulating hormone-responsive pathways and influencing the expression of genes including SCGB2B17. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid, a metabolite of vitamin A, binds to retinoic acid receptors and can enhance secretoglobin activity by influencing gene expression through retinoid response elements, potentially including SCGB2B17. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Vitamin D3, through its active form calcitriol, can enhance secretoglobin activity by binding to the vitamin D receptor, which may interact with vitamin D response elements on secretoglobin genes, including SCGB2B17. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium can enhance the Wnt signaling pathway, which may increase the expression of secretoglobins due to downstream effects on gene transcription regulation, potentially affecting SCGB2B17. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate is a histone deacetylase inhibitor that can enhance gene expression by increasing histone acetylation, potentially leading to upregulation of secretoglobin proteins including SCGB2B17. | ||||||
Hydrocortisone | 50-23-7 | sc-300810 | 5 g | $100.00 | 6 | |
Cortisol, a glucocorticoid hormone, can enhance the activity of secretoglobins by activating glucocorticoid receptors, which might influence the expression of genes encoding secretoglobins and potentially increase SCGB2B17 activity. | ||||||