EG667705 Activators
Fam237b activators represent a class of chemical compounds that enhance the functional activity of the Fam237b protein through various signaling pathways. The activation mechanisms of Fam237b often involve the modulation of cyclic nucleotides such as cAMP and cGMP, which are pivotal second messengers in cellular signaling. Forskolin, Rolipram, IBMX, Epinephrine, Isoproterenol, PGE2, and PACAP-38 all engage pathways that lead to elevated levels of cAMP. The increase in cAMP activates protein kinase A (PKA), which is known to phosphorylate a wide range of cellular proteins. This phosphorylation cascade can result in the activation of proteins that directly or indirectly interact with Fam237b, leading to its functional enhancement. For instance, the activation of PKA bycAMP-elevating compounds like Forskolin and Epinephrine can induce changes in the cellular environment that favor the phosphorylation of proteins associated with Fam237b's functional regulation.
In a similar vein, the inhibition of phosphodiesterases by compounds such as Rolipram and IBMX leads to the accumulation of cAMP, again resulting in PKA activation. The subsequent phosphorylation events are crucial for the modulation of protein interactions and functions that can enhance Fam237b's activity. Additionally, PGE2 operates through its receptors to elevate cAMP levels, leveraging the same PKA-mediated pathway to potentially escalate the activity of Fam237b. Anisomycin, although distinct in its primary action as a protein synthesis inhibitor, indirectly activates JNK, which can phosphorylate transcription factors that upregulate proteins related to Fam237b's function. Other compounds like Spermine and BAY K 8644 influence Fam237b through different mechanisms. Spermine, via NMDA receptor activation, can instigate intracellular signaling cascades that lead to the modification of proteins associated with Fam237b. BAY K 8644, by enhancing calcium influx, can activate calcium-dependent kinases capable of phosphorylating proteins that modulate Fam237b's activity. This exemplifies the diversity in the cellular pathways that can be harnessed to enhance Fam237b's function.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram inhibits phosphodiesterase-4 (PDE4), which prevents the breakdown of cAMP. The resulting higher intracellular cAMP levels activate PKA. PKA potentially phosphorylates regulatory proteins associated with Fam237b, thereby enhancing its function. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, which increases intracellular levels of cAMP and cGMP by inhibiting their degradation. This leads to the activation of PKA and PKG, respectively, potentially enhancing the functional activity of Fam237b via phosphorylation. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine interacts with adrenergic receptors, particularly the β-adrenergic receptors, leading to the activation of adenylyl cyclase and an increase in cAMP levels. The cAMP activates PKA, which then may enhance the activity of Fam237b through phosphorylation. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a synthetic β-adrenergic agonist that activates adenylyl cyclase through the β-adrenergic receptors, increasing cAMP levels and activating PKA, which could enhance the activity of Fam237b via phosphorylation. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
Prostaglandin E2 (PGE2) binds to its G-protein-coupled receptors, leading to an increase in cAMP levels via adenylyl cyclase activation. This can lead to PKA activation and subsequent phosphorylation of proteins that regulate Fam237b activity. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a pyrrolidine antibiotic that activates stress-activated protein kinases (SAPKs) such as JNK. JNK activation can result in the phosphorylation of transcription factors that enhance the expression of proteins interacting with Fam237b, indirectly increasing its functional activity. | ||||||
Spermine | 71-44-3 | sc-212953A sc-212953 sc-212953B sc-212953C | 1 g 5 g 25 g 100 g | $60.00 $192.00 $272.00 $883.00 | 1 | |
Spermine is a polyamine that can activate NMDA receptors that are indirectly involved in the regulation of intracellular signaling pathways, including those that could enhance the functional activity of Fam237b through post-translational modifications. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $82.00 $192.00 $801.00 | ||
BAY K 8644 is an L-type calcium channel agonist that facilitates calcium influx, which can activate calcium-dependent kinases such as calmodulin kinase. These kinases could then phosphorylate proteins that interact with or regulate Fam237b, enhancing its activity. | ||||||
Vardenafil | 224785-90-4 | sc-362054 sc-362054A sc-362054B | 100 mg 1 g 50 g | $516.00 $720.00 $16326.00 | 7 | |
Vardenafil is a selective inhibitor of phosphodiesterase-5 (PDE5), which increases cGMP levels. Elevated cGMP can activate PKG, potentially leading to phosphorylation of proteins that regulate or interact with Fam237b, enhancing its activity. | ||||||