EG628705 Activators
PHD finger protein 11C (PHF11C) activators work by influencing signaling pathways that culminate in the functional upregulation of PHF11C. These compounds typically exert their effects by modulating intracellular second messengers such as cyclic AMP (cAMP), which is a pivotal molecule in various signal transduction pathways. Agents like Forskolin, by directly stimulating adenylyl cyclase, lead to a surge in cAMP levels, which in turn activates protein kinase A (PKA). PKA, a central kinase in many signaling pathways, can phosphorylate a host of downstream targets, including transcription factors that enhance the expression of genes related to PHF11C. This cascade effect ensures that the modulation of signaling pathways by these activators culminates in the enhanced functional activity of PHF11C.
The molecular intricacies of PHF11C activation involve the intricate interplay of enzymes, receptors, and secondary messengers that collectively shape the cellular response. Compounds like Epinephrine and Isoproterenol bind to specific adrenergic receptors, instigating a signaling cascade that ultimately leads to PKA-mediated phosphorylation events. This phosphorylation can affect various substrates within the cell, including those that control the activity state of PHF11C. Moreover, the inhibition of phosphodiesterases by chemicals like IBMX, Rolipram, and Zaprinast results in an accumulation of cAMP, further perpetuating PKA activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine binds to adrenergic receptors, particularly the β-adrenergic subtype, leading to the activation of adenylate cyclase and the subsequent increase in cAMP. This elevation in cAMP activates PKA which can then phosphorylate various target proteins that may include regulators of PHF11C, promoting its activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, enzymes responsible for breaking down cAMP. By inhibiting these enzymes, IBMX causes an increase in cAMP levels, which indirectly promotes the activation of PKA and the subsequent phosphorylation of target proteins that can enhance the function of PHF11C. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
PGE2 interacts with its G-protein coupled E-prostanoid receptors, leading to an increase in intracellular cAMP. This cascade activates PKA, which may phosphorylate proteins involved in the regulation of PHF11C, thereby enhancing its functional activity. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $94.00 $283.00 $988.00 | 7 | |
Histamine binds to H2 receptors which are coupled to the Gs protein, stimulating adenylate cyclase activity and increasing cAMP production. The rise in cAMP activates PKA, potentially leading to the phosphorylation of target proteins that upregulate the activity of PHF11C. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a synthetic β-adrenergic agonist which activates adenylate cyclase through the β-adrenergic receptors, raising intracellular cAMP levels. The activation of PKA by cAMP can lead to the phosphorylation of proteins that enhance the functionality of PHF11C. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase 4 (PDE4), an enzyme that degrades cAMP. By preventing the breakdown of cAMP, rolipram indirectly increases PKA activity, which may result in enhanced function of PHF11C through phosphorylation of associated proteins. | ||||||
Anagrelide | 68475-42-3 | sc-491875 | 25 mg | $150.00 | ||
Anagrelide inhibits phosphodiesterase III (PDE3), leading to increased cAMP levels. The resultant activation of PKA can lead to phosphorylation of proteins that might include those regulating PHF11C, thereby enhancing its activity. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine can bind to D1-like receptors that are coupled to Gs proteins, which activate adenylate cyclase and increase cAMP levels. The cAMP-dependent activation of PKA can then phosphorylate proteins that are involved in the regulation and activation of PHF11C. | ||||||
Terbutaline Hemisulfate | 23031-32-5 | sc-204911 sc-204911A | 1 g 5 g | $92.00 $378.00 | 2 | |
Terbutaline is a β2-adrenergic receptor agonist that increases cAMP by activating adenylate cyclase. The cAMP-mediated activation of PKA may phosphorylate proteins that promote the functional activity of PHF11C. | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $105.00 $250.00 | 8 | |
Zaprinast is a selective inhibitor of phosphodiesterase 5 (PDE5), which leads to elevated cAMP and cGMP levels. This elevation can activate PKA, and the subsequent phosphorylation of proteins can enhance the functional activity of PHF11C. | ||||||