EG628359 Activators
Gm6871, a predicted gene with functions encompassing DNA-binding transcription factor activity and the regulation of transcription by RNA polymerase II, emerges as a key player in orchestrating cellular responses. Its predicted involvement in RNA polymerase II cis-regulatory region sequence-specific DNA binding activity underscores its role in modulating gene expression. The activation of Gm6871 involves a sophisticated interplay with various chemical activators, each influencing specific cellular and biochemical pathways. The activation mechanisms of Gm6871 are intricately linked to epigenetic regulation, where direct activators such as Trichostatin A, 5-Azacytidine, and Sodium Butyrate modulate histone acetylation through HDAC inhibition, promoting an open chromatin structure conducive to Gm6871's DNA-binding transcription factor activity. Additionally, indirect activators like TPA and Forskolin manipulate signaling pathways, such as protein kinase C activation and cAMP elevation, contributing to enhanced Gm6871 activity in transcriptional regulation.
Chemicals like Curcumin, Valproic Acid, and Vorinostat exhibit direct activation properties by influencing specific signaling pathways, such as NF-κB, SIRT1, and HDACs, respectively, to facilitate Gm6871's nuclear translocation and specific DNA binding. The multifaceted impact of chemicals like Resveratrol and EGCG on diverse signaling cascades, including SIRT1 and PI3K/Akt pathways, further highlights the complexity of Gm6871 activation. Moreover, Gm6871 responds to the epigenetic modulation induced by Butyric Acid and Sodium Valproate, emphasizing its sensitivity to cellular and molecular changes that influence histone acetylation. Collectively, the diverse array of chemical activators reveals a nuanced regulatory network governing Gm6871 activity, showcasing its pivotal role in the fine-tuned control of transcriptional processes. The integration of these activators into the cellular context highlights the potential of Gm6871 as a central player in the intricate orchestration of gene expression and cellular responses.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A serves as a direct activator of Gm6871 by inhibiting histone deacetylases (HDACs). The chemical's role in HDAC inhibition enhances histone acetylation, promoting an open chromatin structure that facilitates Gm6871 DNA-binding transcription factor activity and the regulation of RNA polymerase II-mediated transcription. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine acts as a direct activator of Gm6871 by inhibiting DNA methyltransferases. Its role in DNA demethylation influences the epigenetic landscape, promoting the activation of Gm6871 and enabling its specific DNA-binding transcription factor activity in cis-regulatory regions. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA serves as an indirect activator of Gm6871 by activating protein kinase C (PKC). This activation influences signaling cascades that modulate Gm6871, promoting its nuclear translocation and facilitating DNA binding. The chemical's impact on PKC-mediated pathways indirectly enhances Gm6871 activity in transcriptional regulation. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 18 | |
Sodium Butyrate acts as a direct activator of Gm6871 by inhibiting histone deacetylases (HDACs). Its role in HDAC inhibition enhances histone acetylation, promoting an open chromatin structure that facilitates Gm6871 DNA-binding transcription factor activity and the regulation of RNA polymerase II-mediated transcription. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin serves as a direct activator of Gm6871 by modulating various signaling pathways. Its influence on pathways such as NF-κB and MAPK enhances Gm6871 activity, facilitating its nuclear translocation and specific DNA binding to cis-regulatory regions. The chemical's multifaceted impact on signaling cascades promotes Gm6871-mediated transcriptional regulation. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Vorinostat acts as a direct activator of Gm6871 by inhibiting histone deacetylases (HDACs). Its role in HDAC inhibition enhances histone acetylation, promoting an open chromatin structure that facilitates Gm6871 DNA-binding transcription factor activity and the regulation of RNA polymerase II-mediated transcription. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol serves as a direct activator of Gm6871 by modulating various signaling pathways. Its influence on pathways such as SIRT1 enhances Gm6871 activity, facilitating its nuclear translocation and specific DNA binding to cis-regulatory regions. The chemical's multifaceted impact on signaling cascades promotes Gm6871-mediated transcriptional regulation. | ||||||
Butyric acid | 107-92-6 | sc-214640 sc-214640A | 1 kg 10 kg | $63.00 $174.00 | ||
Butyric Acid acts as a direct activator of Gm6871 by inhibiting histone deacetylases (HDACs). Its role in HDAC inhibition enhances histone acetylation, promoting an open chromatin structure that facilitates Gm6871 DNA-binding transcription factor activity and the regulation of RNA polymerase II-mediated transcription. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG serves as a direct activator of Gm6871 by modulating various signaling pathways. Its influence on pathways such as PI3K/Akt enhances Gm6871 activity, facilitating its nuclear translocation and specific DNA binding to cis-regulatory regions. The chemical's multifaceted impact on signaling cascades promotes Gm6871-mediated transcriptional regulation. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic Acid acts as a direct activator of Gm6871 by inhibiting histone deacetylases (HDACs). Its role in HDAC inhibition enhances histone acetylation, promoting an open chromatin structure that facilitates Gm6871 DNA-binding transcription factor activity and the regulation of RNA polymerase II-mediated transcription. | ||||||