EG435927 Activators
Slco1a7, a member of the solute carrier organic anion transporter family, plays a crucial role in bile acid and bile salt transport. Predicted to enable bile acid transmembrane transporter activity and sodium-independent organic anion transmembrane transporter activity, Slco1a7 is integral to the plasma membrane. Its ortholog, SLCO1A2, in humans is implicated in bile acid homeostasis. Activation of Slco1a7 involves a sophisticated interplay of various chemicals that either directly up-regulate the transporter or indirectly influence pathways related to bile acid and organic anion transport. Rifampicin, a well-known inducer of nuclear receptors like PXR, may enhance Slco1a7 expression by inducing pathways involved in bile acid metabolism. Ursodeoxycholic acid, acting as a substrate for Slco1a7, stimulates the transporter, promoting bile acid transport.
Phenobarbital, through its activation of nuclear receptors, can up-regulate Slco1a7 and enhance bile acid and organic anion transport. Rosuvastatin, influencing cholesterol biosynthesis, indirectly activates Slco1a7 and may impact bile acid metabolism. Glycyrrhizin, a natural compound, stimulates Slco1a7 by interacting with nuclear receptors involved in bile acid regulation. Fexofenadine, acting as a substrate for Slco1a7, may up-regulate the transporter and influence organic anion transport. Cholic acid, Emodin, Efavirenz, Bezafibrate, Tauroursodeoxycholic acid, and Sulforaphane contribute to Slco1a7 activation through various mechanisms, including substrate activity, modulation of nuclear receptors, and influence on bile acid metabolism pathways. In summary, Slco1a7 activation is orchestrated by a diverse array of chemicals that intricately modulate its role in bile acid and organic anion transport. The complex interplay of these chemicals highlights the sophisticated regulation of Slco1a7 and provides potential avenues for further exploration in understanding and manipulating bile acid homeostasis.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $97.00 $328.00 $676.00 $1467.00 | 6 | |
Rifampicin may up-regulate Slco1a7 by inducing nuclear receptors involved in bile acid metabolism. This antibiotic influences the pregnane X receptor (PXR), potentially enhancing bile acid transport. | ||||||
Ursodeoxycholic acid | 128-13-2 | sc-204935 sc-204935A | 1 g 5 g | $52.00 $131.00 | 4 | |
Ursodeoxycholic acid, a bile acid derivative, may stimulate Slco1a7 by acting as a substrate for the transporter. It could promote bile acid transport, influencing pathways associated with Slco1a7 activation. | ||||||
Rosuvastatin | 287714-41-4 | sc-481834 | 10 mg | $145.00 | 8 | |
Rosuvastatin, a statin drug, may indirectly activate Slco1a7 by modulating cholesterol biosynthesis. Its impact on bile acid metabolism and transport pathways could contribute to Slco1a7 stimulation. | ||||||
Glycyrrhizic acid | 1405-86-3 | sc-279186 sc-279186A | 1 g 25 g | $57.00 $333.00 | 7 | |
Glycyrrhizic acid, a natural compound, may stimulate Slco1a7 by influencing nuclear receptors involved in bile acid regulation. Its interaction with PXR and FXR could enhance bile acid transport and metabolism. | ||||||
Fexofenadine | 83799-24-0 | sc-218475 | 100 mg | $298.00 | 1 | |
Fexofenadine, an antihistamine, may up-regulate Slco1a7 by acting as a substrate for the transporter. Its potential modulation of organic anion transport pathways could contribute to Slco1a7 activation. | ||||||
Cholic acid | 81-25-4 | sc-255020 sc-255020A sc-255020B sc-255020C sc-255020D | 25 g 100 g 500 g 1 kg 5 kg | $49.00 $123.00 $578.00 $1018.00 $4570.00 | 11 | |
Cholic acid, a primary bile acid, may stimulate Slco1a7 by acting as a substrate for the transporter. Its presence could enhance bile acid transport and influence pathways associated with Slco1a7 activation. | ||||||
Emodin | 518-82-1 | sc-202601 sc-202601A sc-202601B | 50 mg 250 mg 15 g | $105.00 $214.00 $6255.00 | 2 | |
Emodin, a natural compound, may activate Slco1a7 by interacting with nuclear receptors regulating bile acid metabolism. Its modulation of bile acid transport pathways could contribute to Slco1a7 up-regulation. | ||||||
Efavirenz | 154598-52-4 | sc-207612 | 10 mg | $171.00 | 3 | |
Efavirenz, an antiretroviral drug, may indirectly stimulate Slco1a7 by influencing drug-metabolizing enzymes and transporters. Its impact on bile acid metabolism and transport pathways could contribute to activation. | ||||||
Bezafibrate | 41859-67-0 | sc-204650B sc-204650 sc-204650A sc-204650C | 500 mg 1 g 5 g 10 g | $31.00 $46.00 $122.00 $204.00 | 5 | |
Bezafibrate, a fibrate drug, may up-regulate Slco1a7 by modulating nuclear receptors involved in bile acid regulation. Its influence on bile acid transport pathways could contribute to Slco1a7 activation. | ||||||
Tauroursodeoxycholic Acid, Sodium Salt | 14605-22-2 | sc-281165 | 1 g | $644.00 | 5 | |
Tauroursodeoxycholic acid, a bile acid derivative, may stimulate Slco1a7 by acting as a substrate for the transporter. Its presence could enhance bile acid transport and influence pathways associated with Slco1a7 activation. | ||||||