EG434729 Activators

Fthl17f, a member of the ferritin heavy chain-like family, stands as a pivotal player in cellular iron homeostasis, exhibiting predicted ferric and ferrous iron binding activities. Its role in intracellular sequestering of iron ions within the cytoplasm, especially during early conceptus development, underscores its critical function in fundamental biological processes. The orthologous relationship to human FTHL17 further emphasizes its evolutionary conservation and potential functional significance in iron regulation.

The activation of Fthl17f involves a sophisticated interplay of chemical regulators that exert their influence through various cellular pathways. RGFP966, an HDAC3 inhibitor, enhances Fthl17f expression by promoting chromatin accessibility and facilitating transcription factor binding. SP600125, a JNK inhibitor, indirectly activates Fthl17f by modulating the JNK pathway, influencing downstream targets associated with iron ion homeostasis. Forskolin, a cAMP activator, up-regulates Fthl17f through PKA-mediated pathways, enhancing its transcriptional activity. CAY10602, a GSK-3β inhibitor, indirectly promotes Fthl17f expression by modulating GSK-3β signaling and its downstream targets. A769662, an AMPK activator, influences AMPK/mTOR pathways, indirectly activating Fthl17f by modulating cellular energy sensing.