EG382275 Activators
Gm5168, a predicted gene with implications in meiotic cell cycle progression and spermatid development, plays a pivotal role in orchestrating crucial events during the process of reproduction. Its predicted involvement in the synaptonemal complex, a structure essential for proper chromosome pairing and recombination during meiosis, underscores its significance in ensuring accurate and error-free segregation of genetic material. The identification of human ortholog SYCP3 further underscores the evolutionary conservation of its function, emphasizing its critical role in reproductive processes across species. The function of Gm5168 revolves around its participation in the intricate dance of meiotic events. As cells undergo meiosis, Gm5168 contributes to the formation and stability of the synaptonemal complex, which serves as a scaffold for homologous chromosomes to align and exchange genetic material. This function is crucial for the generation of genetic diversity and the production of viable, genetically distinct gametes. Furthermore, its association with spermatogenic failure 4 in humans suggests its involvement in the pathogenesis of conditions affecting male fertility, highlighting the relevance of understanding its activation mechanisms.
The activation of Gm5168 involves a sophisticated interplay of various regulatory mechanisms that collectively contribute to its participation in meiotic cell cycle progression and spermatid development. Epigenetic modifiers, such as histone deacetylase and methyltransferase inhibitors, dynamically influence chromatin structure to promote Gm5168 expression. These modifications, occurring at the level of histones, regulate the accessibility of the genetic material and contribute to the precise orchestration of meiotic events. Additionally, modulation of key signaling pathways, including Wnt, MAPK, and PI3K/Akt, indirectly activates Gm5168 by influencing cellular cascades that are crucial for meiotic cell cycle regulation. These signaling pathways serve as conduits for extracellular signals to be translated into intracellular responses, ultimately impacting the expression and function of Gm5168 in the context of meiotic events. The intricate regulatory network governing Gm5168 activation provides a nuanced understanding of its role in reproductive biology and contributes to our broader comprehension of the complex processes underlying meiosis and spermatid development.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium Butyrate, a histone deacetylase inhibitor, induces histone hyperacetylation, impacting chromatin structure. This epigenetic modification positively regulates Gm5168 expression, promoting its involvement in meiotic cell cycle progression and spermatid development. Sodium Butyrate acts as an indirect activator through the modulation of histone acetylation. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
5-Aza-2'-deoxycytidine, a DNA methyltransferase inhibitor, alters DNA methylation patterns, influencing gene expression. This epigenetic modification positively regulates Gm5168, contributing to its role in meiotic cell cycle regulation and spermatid development. The compound serves as an indirect activator through the modulation of DNA methylation dynamics. | ||||||
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $71.00 $202.00 | 18 | |
SB216763, a GSK-3 inhibitor, impacts Wnt signaling. Inhibition of GSK-3 positively influences Gm5168 expression, contributing to meiotic cell cycle progression. SB216763 serves as an indirect activator by modulating the Wnt signaling pathway and promoting the activation of Gm5168 involved in spermatid development. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR, an AMP-activated protein kinase (AMPK) activator, influences cellular energy sensing. AMPK activation positively regulates Gm5168, contributing to meiotic cell cycle regulation. AICAR serves as an indirect activator by modulating AMPK and promoting the activation of Gm5168 involved in spermatid development. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
TSA (Trichostatin A), a histone deacetylase inhibitor, induces histone hyperacetylation. This epigenetic modification positively regulates Gm5168 expression, contributing to its role in meiotic cell cycle progression and spermatid development. TSA serves as an indirect activator through the modulation of histone acetylation dynamics. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Suberoylanilide Hydroxamic Acid, a histone deacetylase inhibitor, induces histone hyperacetylation. This epigenetic modification positively regulates Gm5168 expression, contributing to its role in meiotic cell cycle progression and spermatid development. Vorinostat serves as an indirect activator through the modulation of histone acetylation dynamics. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
Roscovitine, a cyclin-dependent kinase (CDK) inhibitor, disrupts cell cycle progression. Inhibition of CDK positively influences Gm5168 expression, contributing to meiotic cell cycle regulation. Roscovitine serves as an indirect activator by modulating CDK activity and promoting the activation of Gm5168 involved in spermatid development. | ||||||
Histone Lysine Methyltransferase Inhibitor Inhibitor | 935693-62-2 (free base) | sc-202651 | 5 mg | $151.00 | 4 | |
BIX-01294, a histone methyltransferase inhibitor, alters histone methylation patterns. This epigenetic modification positively regulates Gm5168 expression, contributing to its role in meiotic cell cycle progression and spermatid development. BIX-01294 serves as an indirect activator through the modulation of histone methylation dynamics. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
JQ1, a bromodomain and extraterminal (BET) inhibitor, disrupts chromatin interactions. Inhibition of BET proteins positively influences Gm5168 expression, contributing to its role in meiotic cell cycle progression and spermatid development. JQ1 serves as an indirect activator through the modulation of chromatin structure and dynamics. | ||||||