EG245263 Inhibitors
Duxf4, a double homeobox family member, plays a crucial role as a DNA-binding transcription factor involved in the regulation of transcription by RNA polymerase II. Predicted to function in the nucleus, it exerts its regulatory influence through sequence-specific DNA binding in transcriptional regions. Inhibition of Duxf4 involves a strategic selection of chemical compounds targeting various aspects of the transcriptional machinery. Actinomycin D, Flavopiridol, and Camptothecin disrupt RNA polymerase II activity, indirectly affecting Duxf4's role in transcriptional regulation. Alpha-Amanitin and 5,6-Dichlorobenzimidazole target RNA polymerase II, hindering its function and subsequently impacting Duxf4's DNA-binding activity. Compounds like Cisplatin, Triptolide, and Fludarabine induce DNA damage, compromising the integrity of Duxf4's binding sites and disrupting its regulatory region interactions.
Thiolutin, 8-Azaguanine, and Mycophenolic Acid interfere with nucleotide metabolism, influencing the availability of essential building blocks for transcription. This indirectly hinders Duxf4's ability to bind DNA and regulate transcription by RNA polymerase II. In conclusion, understanding the inhibition of Duxf4 involves a nuanced exploration of compounds targeting different components of the transcriptional machinery, providing a diverse toolkit for researchers dissecting its regulatory role in RNA polymerase II-mediated transcription.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D inhibits RNA polymerase by intercalating into DNA, preventing transcription initiation. Its interference with RNA polymerase II activity indirectly inhibits Duxf4's DNA-binding transcription factor function, disrupting regulatory region interactions. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $254.00 | 41 | |
Flavopiridol, a cyclin-dependent kinase inhibitor, hinders RNA polymerase II-mediated transcription. By modulating CDKs, it indirectly influences Duxf4 activity, disrupting its DNA-binding capacity and regulatory region sequence-specific interactions. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Camptothecin inhibits topoisomerase I, inducing DNA damage. This leads to the impairment of RNA polymerase II transcription. The consequential disruption of transcriptional regulation indirectly interferes with Duxf4's predicted DNA-binding transcription factor activity. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
Alpha-Amanitin selectively inhibits RNA polymerase II. Its interference with transcription initiation and elongation indirectly affects Duxf4's role as a DNA-binding transcription factor, hindering its ability to regulate transcription by RNA polymerase II. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $42.00 $185.00 $310.00 $650.00 | 6 | |
DRB inhibits CDK7, a key regulator of the transcription process. By targeting CDK7, it indirectly disrupts Duxf4's RNA polymerase II transcription regulatory region sequence-specific DNA binding activity, impeding its function as a transcriptional regulator. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $76.00 $216.00 | 101 | |
Cisplatin induces DNA cross-linking, causing DNA damage. This disruption of DNA integrity indirectly influences Duxf4's function as a DNA-binding transcription factor by compromising its binding sites, consequently impacting its regulatory region sequence-specific DNA binding activity. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
Triptolide inhibits RNA polymerase II-mediated transcription by disrupting the transcriptional machinery. Its indirect impact on transcription regulation interferes with Duxf4's DNA-binding transcription factor activity and regulatory region sequence-specific interactions. | ||||||
Fludarabine | 21679-14-1 | sc-204755 sc-204755A | 5 mg 25 mg | $57.00 $200.00 | 15 | |
Fludarabine inhibits RNA polymerase II by inducing DNA damage. Its interference with transcription initiation and elongation indirectly affects Duxf4's DNA-binding transcription factor function, disrupting its regulatory region sequence-specific interactions. | ||||||
Thiolutin | 87-11-6 | sc-200387 sc-200387A | 1 mg 5 mg | $99.00 $398.00 | 1 | |
Thiolutin inhibits RNA polymerase II transcription. Its interference with the transcription process indirectly hinders Duxf4's predicted DNA-binding transcription factor activity, disrupting its ability to bind to regulatory regions and regulate RNA polymerase II-mediated transcription. | ||||||
8-Azaguanine | 134-58-7 | sc-207194 sc-207194A | 1 g 5 g | $82.00 $208.00 | 1 | |
8-Azaguanine inhibits RNA synthesis by interfering with guanine nucleotide metabolism. Its impact on nucleotide availability indirectly disrupts Duxf4's DNA-binding transcription factor function, affecting its ability to regulate transcription by RNA polymerase II. | ||||||