EAF2 Inhibitors
EAF2 inhibitors belong to a distinctive class of chemical compounds that specifically target the EAF2 (ELL-associated factor 2) protein, a critical player in cellular processes. EAF2, also known as TRIM8 (Tripartite motif-containing protein 8), is a member of the tripartite motif (TRIM) protein family, which is involved in various cellular functions, including transcriptional regulation and protein degradation. The development of EAF2 inhibitors stems from the growing recognition of the role played by EAF2 in modulating gene expression and cellular homeostasis.
The chemical structure of EAF2 inhibitors is meticulously designed to interact with the active site of the EAF2 protein, impeding its normal function. These inhibitors often possess specific molecular motifs that enable them to bind selectively to EAF2, disrupting its interactions with other cellular components.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
ICI 182,780 | 129453-61-8 | sc-203435 sc-203435A | 1 mg 10 mg | $83.00 $187.00 | 34 | |
Interacts with estrogen receptors, which can downregulate signaling pathways involving EAF2. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
An MEK inhibitor that may disrupt MAPK/ERK signaling, indirectly affecting pathways associated with EAF2. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Histone deacetylase inhibitor that can change gene expression patterns, including those involving EAF2. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
Inhibits p38 MAPK, which could have effects on cellular processes involving EAF2. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
A PI3K inhibitor similar to LY294002, possibly affecting PI3K-dependent pathways involving EAF2. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $67.00 $156.00 | 16 | |
Inhibits Hsp90 which may disrupt protein folding processes, thus potentially affecting EAF2 function. | ||||||