EAAT2 Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(2S,4R)-4-Methylglutamic Acid | 31137-74-3 | sc-216338 | 5 mg | $171.00 | ||
Inhibits EAAT2, a protein involved in regulating glutamate levels in the brain. It may do so by competitively binding to the transporter's substrate binding site, disrupting normal glutamate transport and potentially affecting neurotransmission. | ||||||
Dihydrokainic acid | 52497-36-6 | sc-200442B sc-200442 sc-200442A | 1 mg 10 mg 50 mg | $110.00 $302.00 $914.00 | 3 | |
Dihydrokainic acid is a potent inhibitor of excitatory amino acid transporters (EAAT2), distinguished by its unique structural conformation that facilitates specific binding interactions. Its dual carboxyl functionalities enable robust electrostatic interactions with the transporter, enhancing affinity. The compound exhibits notable reaction kinetics, characterized by a rapid association rate, which may influence the dynamics of glutamate uptake and modulate synaptic transmission efficiency. | ||||||
L-(-)-threo-3-Hydroxyaspartic acid | 7298-99-9 | sc-204033 | 10 mg | $218.00 | 1 | |
L-(-)-threo-3-Hydroxyaspartic acid acts as a selective modulator of excitatory amino acid transporters (EAAT2), featuring a unique stereochemistry that promotes specific interactions with the transporter. Its hydroxyl group enhances hydrogen bonding capabilities, influencing the conformational dynamics of the transporter. This compound exhibits distinct reaction kinetics, with a notable propensity for competitive inhibition, potentially altering glutamate homeostasis and synaptic signaling pathways. | ||||||
L-trans-Pyrrolidine-2,4-dicarboxylic acid | 64769-66-0 | sc-200477 sc-200477A | 5 mg 25 mg | $66.00 $419.00 | 8 | |
L-trans-Pyrrolidine-2,4-dicarboxylic acid is a potent modulator of excitatory amino acid transporters (EAAT2), characterized by its unique cyclic structure that facilitates specific binding interactions. The presence of two carboxyl groups allows for enhanced electrostatic interactions, influencing the transporter's conformational states. This compound exhibits unique reaction kinetics, demonstrating a capacity for allosteric modulation, which can significantly impact glutamate uptake and neuronal signaling dynamics. | ||||||
Diethylmaleate | 141-05-9 | sc-202577 | 5 g | $27.00 | 4 | |
Diethylmaleate (DEM) is a potential inhibitor that might affect EAAT2 function by modulating the redox state of the transporter, thereby altering its activity and glutamate uptake capacity. | ||||||
WAY 213613 | 868359-05-1 | sc-203720 sc-203720A | 10 mg 50 mg | $199.00 $842.00 | ||
A potential EAAT2 inhibitor that might interfere with glutamate reuptake, potentially affecting synaptic glutamate levels. | ||||||
(±)-threo-3-Methylglutamic acid | 63088-04-0 | sc-204344 sc-204344A | 5 mg 50 mg | $318.00 $1570.00 | ||
Inhibits EAAT2 by binding to its active site or substrate binding site, interfering with its ability to transport glutamate. This disruption can lead to altered glutamate clearance, affecting neurotransmission and potentially contributing to neurological processes. For detailed insights, referring to scientific literature or research articles is recommended. | ||||||
UCPH 101 | 1118460-77-7 | sc-361391 sc-361391A | 10 mg 50 mg | $388.00 $908.00 | 3 | |
UCPH-101 is an EAAT2-specific inhibitor that might impact glutamate reuptake and synaptic transmission by interacting with the transporter's binding sites. | ||||||