Molecular structure of (±)-threo-3-Methylglutamic acid, CAS Number: 63088-04-0
(±)-threo-3-Methylglutamic acid (CAS 63088-04-0)
Alternate Names:
(2R,3S)-2-amino-3-methylpentanedioic acid; T3MG; threo-3-Methylglutamate
Application:
(±)-threo-3-Methylglutamic acid is a glutamate transport blocker selective for EAAT2 and EAAT4
CAS Number:
63088-04-0
Molecular Weight:
161.16
Molecular Formula:
C6H11NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
(±)-threo-3-Methylglutamic acid is a potent blocker of glutamate transport. (±)-threo-3-Methylglutamic acid is selective for EAAT2 and EAAT4 (IC50 values are 90, 109, 1600 and 1080 muM for EAAT2, EAAT4, EAAT1 and EAAT3 respectively). (±)-threo-3-Methylglutamic acid is a naturally occurring non-proteinogenic amino acid found in select plants and bacteria. Its structural resemblance to glutamic acid, a neurotransmitter in the central nervous system, has drawn scientific interest. Extensive research has explored the potential applications of 3-Methylglutamic acid, including its utility as a foundational component for the synthesis of novel peptides and its role as a chiral auxiliary in asymmetric synthesis.
(±)-threo-3-Methylglutamic acid (CAS 63088-04-0) References
- Identification of functional domains of the human glutamate transporters EAAT1 and EAAT2. | Mitrovic, AD., et al. 1998. J Biol Chem. 273: 14698-706. PMID: 9614067
Inhibitor of:
EAAT2, and EAAT4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(±)-threo-3-Methylglutamic acid, 5 mg | sc-204344 | 5 mg | $312.00 | |||
(±)-threo-3-Methylglutamic acid, 50 mg | sc-204344A | 50 mg | $1539.00 |