Molecular structure of UCPH 101, CAS Number: 1118460-77-7
UCPH 101 (CAS 1118460-77-7)
See product citations (3)
Alternate Names:
2-Amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile
Application:
UCPH 101 is a selective inhibitor of EAAT1
CAS Number:
1118460-77-7
Purity:
≥93%
Molecular Weight:
422.48
Molecular Formula:
C27H22N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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UCPH 101 is a selective inhibitor of the excitatory amino acid transporter subtype 1 (EAAT1), which is extensively used in neuroscientific research. Investigations involving UCPH 101 often focus on the role of glutamate transporters in synaptic transmission and plasticity. By inhibiting EAAT1, researchers are able to study the consequences of disrupted glutamate uptake on neuronal function and excitotoxicity. UCPH 101 is also used to explore the involvement of EAAT1 in neurological conditions and to understand the transporter′s distribution and regulation in the central nervous system. Moreover, this compound assists in characterizing the pharmacological profile of EAAT1 and in screening for potential modulators of glutamatergic signaling.
UCPH 101 (CAS 1118460-77-7) References
- Structure-activity relationship study of first selective inhibitor of excitatory amino acid transporter subtype 1: 2-Amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-101). | Erichsen, MN., et al. 2010. J Med Chem. 53: 7180-91. PMID: 20857912
- The glutamate aspartate transporter (GLAST) mediates L-glutamate-stimulated ascorbate-release via swelling-activated anion channels in cultured neonatal rodent astrocytes. | Lane, DJ. and Lawen, A. 2013. Cell Biochem Biophys. 65: 107-19. PMID: 22886112
- Design, synthesis and pharmacological characterization of coumarin-based fluorescent analogs of excitatory amino acid transporter subtype 1 selective inhibitors, UCPH-101 and UCPH-102. | Huynh, TH., et al. 2012. Bioorg Med Chem. 20: 6831-9. PMID: 23072958
- Allosteric modulation of an excitatory amino acid transporter: the subtype-selective inhibitor UCPH-101 exerts sustained inhibition of EAAT1 through an intramonomeric site in the trimerization domain. | Abrahamsen, B., et al. 2013. J Neurosci. 33: 1068-87. PMID: 23325245
- Probing for improved potency and in vivo bioavailability of excitatory amino acid transporter subtype 1 inhibitors UCPH-101 and UCPH-102: design, synthesis and pharmacological evaluation of substituted 7-biphenyl analogs. | Erichsen, MN., et al. 2014. Neurochem Res. 39: 1964-79. PMID: 24682739
- Pharmacological inhibitions of glutamate transporters EAAT1 and EAAT2 compromise glutamate transport in photoreceptor to ON-bipolar cell synapses. | Tse, DY., et al. 2014. Vision Res. 103: 49-62. PMID: 25152321
- Neurosurgical management of a large meningocele in Jarcho-Levin syndrome: clinical and radiological pearls. | Martinez Santos, JL., et al. 2015. BMJ Case Rep. 2015: PMID: 26199296
- New Insight into the Structure-Activity Relationships of the Selective Excitatory Amino Acid Transporter Subtype 1 (EAAT1) Inhibitors UCPH-101 and UCPH-102. | Hansen, SW., et al. 2016. ChemMedChem. 11: 382-402. PMID: 26757239
- Bioavailability Studies and in vitro Profiling of the Selective Excitatory Amino Acid Transporter Subtype 1 (EAAT1) Inhibitor UCPH-102. | Haym, I., et al. 2016. ChemMedChem. 11: 403-19. PMID: 26797816
- Altered function of the glutamate-aspartate transporter GLAST, a potential therapeutic target in glioblastoma. | Corbetta, C., et al. 2019. Int J Cancer. 144: 2539-2554. PMID: 30418668
- Ion transport and regulation in a synaptic vesicle glutamate transporter. | Li, F., et al. 2020. Science. 368: 893-897. PMID: 32439795
- Selective Clearance of Senescent Chondrocytes in Osteoarthritis by Targeting Excitatory Amino Acid Transporter Protein 1 to Induce Ferroptosis. | Wen, Z., et al. 2023. Antioxid Redox Signal.. PMID: 36601724
- Conserved allosteric inhibition mechanism in SLC1 transporters. | Dong, Y., et al. 2023. Elife. 12: PMID: 36856089
Inhibitor of:
EAAT-4, EAAT-5, EAAT1, EAAT2, EAAT3, EAAT4, EAAT5, and VGLUT3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
UCPH 101, 10 mg | sc-361391 | 10 mg | $380.00 | |||
UCPH 101, 50 mg | sc-361391A | 50 mg | $890.00 |