Dihydrokainic acid CAS: 52497-36-6
MF: C10H17NO4
MW: 215.3
An EAAT2(GLT1)-selective non-transportable inhibitor of L-glutamate and L-aspartate uptake.

Dihydrokainic acid (CAS 52497-36-6)

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Alternate Names: 2-Carboxy-4-isopropyl-3-pyrrolidineacetic acid
Application: Dihydrokainic acid is an EAAT2(GLT1)-selective non-transportable inhibitor of L-glutamate and L-aspartate uptake
CAS Number: 52497-36-6
Molecular Weight: 215.3
Molecular Formula: C10H17NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Dihydrokainic acid is an EAAT2 (GLT1)-selective non-transportable inhibitor of L-glutamate and L-aspartate uptake (Ki = 23 μM). Dihydrokainic acid is 130-fold selective over EAAT1 and EAAT3 (Ki > 3 mM).


References

1. Olney, J.W., et al. 1974. Brain Res. 77: 507-512. PMID: 4152936
2. Watkins, J.C., et al. 1981. Annu. Rev. Pharmacol. Toxicol. 21: 165-204. PMID: 6112965
3. Ferkany, J.W., et al. 1982. Nature. 298: 757-759. PMID: 6287270
4. Huettner, J.E. 2003. Prog. Neurobiol. 70: 387-407. PMID: 14511698
5. Marsicano, G., et al. 2003. Science. 302: 84-88. PMID: 14526074

Physical State :
Solid
Solubility :
Soluble in water (>10 mg/ml), phosphate buffered saline (100 mM), and 1eq NaOH (100 mM).
Storage :
Store at 4° C
Refractive Index :
n20D 1.49 (Predicted)
IC50 :
Rattus norvegicus: IC50 = 645.6 nM (rat)
Ki Data :
Glutamate receptor ionotropic kainate 3: Ki= 363.08 nM (rat); L-gulamate: Ki= 23 µM; L-aspartate: Ki= 23 µM; Glutamate receptor ionotropic kainate 1: Ki= 8.13 µM (rat); Excitatory amino acid transporter 2: Ki= 9 µM (human); EAAT1: Ki= >3 mM; EAAT3: Ki= >3 mM
pK Values :
pKa: 2.11 (Predicted), pKb: 11 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
107883
MDL Number :
MFCD03412037
SMILES :

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Certificate of Analysis

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Dihydrokainic acid (CAS 52497-36-6)  Product Citations

See how others have used Dihydrokainic acid (CAS 52497-36-6). Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 26732600  Wang, X. et al. 2017. Mol. Neurobiol. 54: 175-187.

PMID: # 32724478  Theranostics. 8415-8429.

Citations 1 to 2 of 2 total
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