EAAT1 Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
UCPH 101 | 1118460-77-7 | sc-361391 sc-361391A | 10 mg 50 mg | $388.00 $908.00 | 3 | |
UCPH 101 is a selective modulator of excitatory amino acid transporters (EAAT1), characterized by its unique structural features that facilitate specific hydrogen bonding and electrostatic interactions with the transporter. Its distinct molecular architecture promotes conformational flexibility, enhancing the efficiency of substrate translocation. Additionally, UCPH 101 influences the allosteric regulation of the transporter, potentially altering the dynamics of glutamate uptake and release, thereby affecting synaptic signaling pathways. | ||||||
L-(-)-threo-3-Hydroxyaspartic acid | 7298-99-9 | sc-204033 | 10 mg | $218.00 | 1 | |
L-(-)-threo-3-Hydroxyaspartic acid acts as a potent modulator of excitatory amino acid transporters (EAAT1), exhibiting unique stereochemistry that enhances its binding affinity. Its hydroxyl group facilitates specific interactions with the transporter, promoting optimal substrate recognition. The compound's kinetic profile reveals rapid association and dissociation rates, allowing for efficient transport dynamics. Furthermore, it may influence the conformational states of EAAT1, impacting glutamate homeostasis. | ||||||
(S)-MCPG | 150145-89-4 | sc-202329 sc-202329A | 5 mg 25 mg | $146.00 $964.00 | ||
(S)-MCPG, a selective group I/II metabotropic glutamate receptor antagonist, indirectly influences EAAT1 by blocking glutamate receptors. By preventing excessive glutamate receptor activation, (S)-MCPG modulates glutamate levels, indirectly impacting EAAT1 activity. | ||||||
L-trans-Pyrrolidine-2,4-dicarboxylic acid | 64769-66-0 | sc-200477 sc-200477A | 5 mg 25 mg | $66.00 $419.00 | 8 | |
L-trans-Pyrrolidine-2,4-dicarboxylic acid serves as a selective inhibitor of excitatory amino acid transporters (EAAT1), characterized by its unique cyclic structure that enhances its interaction with the transporter. The presence of two carboxyl groups allows for multiple hydrogen bonding opportunities, stabilizing the binding complex. Its distinct reaction kinetics demonstrate a slower dissociation rate, which may prolong its effects on glutamate transport and influence neuronal signaling pathways. | ||||||
Dihydrokainic acid | 52497-36-6 | sc-200442B sc-200442 sc-200442A | 1 mg 10 mg 50 mg | $110.00 $302.00 $914.00 | 3 | |
Dihydrokainate, a non-transportable substrate analog, indirectly influences EAAT1 by competitively inhibiting glutamate transport. By mimicking the structure of glutamate, Dihydrokainate competes for binding to EAAT1, preventing the transport of endogenous substrates. | ||||||
Evans Blue | 314-13-6 | sc-203736B sc-203736 sc-203736A | 1 g 10 g 50 g | $47.00 $69.00 $265.00 | 15 | |
Evans Blue, a blood-brain barrier impermeant dye, indirectly influences EAAT1 by binding to extracellular glutamate. By sequestering glutamate in the extracellular space, Evans Blue modulates glutamate levels, indirectly impacting EAAT1 activity. This indirect inhibition offers insights into the consequences of altered glutamate clearance by EAAT1, providing a tool for studying the regulatory mechanisms governing glutamate homeostasis and its impact on neuroexcitability. | ||||||
L-α-Aminoadipic acid | 1118-90-7 | sc-202200 sc-202200A | 50 mg 250 mg | $19.00 $32.00 | ||
L-α-Aminoadipic Acid, a non-transportable substrate analog, indirectly influences EAAT1 by competitively inhibiting glutamate transport. By mimicking the structure of glutamate, L-α-Aminoadipic Acid competes for binding to EAAT1, preventing the transport of endogenous substrates. | ||||||
(S)-(+)-N-Benzylserine | 17136-45-7 | sc-220044 | 1 g | $205.00 | 1 | |
Benzylserine, an L-serine analog, indirectly influences EAAT1 by competitively inhibiting glutamate transport. By mimicking the structure of the endogenous substrate L-serine, Benzylserine competes for binding to EAAT1, preventing the transport of glutamate. | ||||||