Molecular structure of L-α-Aminoadipic acid, CAS Number: 1118-90-7
L-α-Aminoadipic acid (CAS 1118-90-7)
Alternate Names:
(S)-2-Aminohexanedioic acid
Application:
L-α-Aminoadipic acid is an inhibitor of ischemic glutamate release
CAS Number:
1118-90-7
Purity:
98%
Molecular Weight:
161.16
Molecular Formula:
C6H11NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
L-α-Aminoadipic acid, a gliotoxic analogue of glutamate, may act to competitively inhibit the transport protein of D-[3H]-aspartate. Experiments have reported that this compound also causes a reduction in ischemic glutamate release in murine hippocampal slices in vitro. Additional research suggests that L-alpha-Aminoadipic acid inhibits astrocyte culture Kynurenic acid (sc-202683) synthesis which demonstrates the ability to modulate neuronal degeneration. L-alpha-Aminoadipic acid is a inhibitor of GluR and Gl Syn.
L-α-Aminoadipic acid (CAS 1118-90-7) References
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- Astrocytic activation in thoracic spinal cord contributes to persistent pain in rat model of chronic pancreatitis. | Feng, QX., et al. 2010. Neuroscience. 167: 501-9. PMID: 20149842
- L-pipecolic acid metabolism in human liver: L-alpha-aminoadipate delta-semialdehyde oxidoreductase. | Chang, YF., et al. 1990. Biochim Biophys Acta. 1038: 300-5. PMID: 2160277
- Inhibitors of the NMDA-Nitric Oxide Signaling Pathway Protect Against Neuronal Atrophy and Synapse Loss Provoked by l-alpha Aminoadipic Acid-treated Astrocytes. | David, J., et al. 2018. Neuroscience. 392: 38-56. PMID: 30267830
- L-alpha-amino adipic acid provokes depression-like behaviour and a stress related increase in dendritic spine density in the pre-limbic cortex and hippocampus in rodents. | David, J., et al. 2019. Behav Brain Res. 362: 90-102. PMID: 30639510
- L-alpha-aminoadipic acid restricts dopaminergic neurodegeneration and motor deficits in an inflammatory model of Parkinson's disease in male rats. | O'Neill, E., et al. 2019. J Neurosci Res. 97: 804-816. PMID: 30924171
- A comparison of the effects of isomers of alpha-aminoadipic acid and 2-amino-4-phosphonobutyric acid on the light response of the müller glial cell and the electroretinogram. | Zimmerman, RP. and Corfman, TP. 1984. Neuroscience. 12: 77-84. PMID: 6462455
- Gliotoxic effects of alpha-aminoadipic acid on monolayer cultures of dissociated postnatal mouse cerebellum. | Huck, S., et al. 1984. Neuroscience. 12: 783-91. PMID: 6472620
- Inhibition of the glutamate transporter and glial enzymes in rat striatum by the gliotoxin, alpha aminoadipate. | McBean, GJ. 1994. Br J Pharmacol. 113: 536-40. PMID: 7834205
- L-alpha-aminoadipic acid as a regulator of kynurenic acid production in the hippocampus: a microdialysis study in freely moving rats. | Wu, HQ., et al. 1995. Eur J Pharmacol. 281: 55-61. PMID: 8566117
- Characterization of L-alpha-aminoadipic acid transport in cultured rat astrocytes. | Tsai, MJ., et al. 1996. Brain Res. 741: 166-73. PMID: 9001719
- L-alpha-aminoadipate reduces glutamate release from brain tissue exposed to combined oxygen and glucose deprivation. | Haugstad, TS. and Langmoen, IA. 1997. J Cereb Blood Flow Metab. 17: 567-70. PMID: 9183295
- L-alpha-aminoadipate inhibits kynurenate synthesis in rat brain hippocampus and tissue culture. | Chang, YF., et al. 1997. Neurochem Res. 22: 825-9. PMID: 9232635
Inhibitor of:
EAAT1, and Gl Syn.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L-α-Aminoadipic acid, 50 mg | sc-202200 | 50 mg | $19.00 | |||
L-α-Aminoadipic acid, 250 mg | sc-202200A | 250 mg | $31.00 |