DUSP8 Activators
DUSP8 Activators are a diverse group of chemical compounds that indirectly enhance the functional activity of DUSP8, a protein involved in the regulation of the MAPK signaling pathway. Compounds like Forskolin and A23187 work by increasing intracellular levels of cAMP and calcium, respectively. These elevations lead to the activation of PKA and calcium-dependent signaling pathways, which intersect with MAPK signaling, thereby enhancing DUSP8's role in this pathway. Similarly, LY 294002 and Rapamycin, inhibitors of PI3K and mTOR respectively, modulate other signaling pathways (PI3K/AKT and mTOR) that have cross-talk with MAPK signaling, ultimately leading to the enhancement of DUSP8 activity. Additionally, U0126 and SB 203580, which inhibit MEK1/2 and p38 MAPK, shift the signaling balance towards pathways where DUSP8 is a key regulator, thus enhancing its functional activity.
In the same vein, compounds like D-erythro-Sphingosine-1-phosphate and Thapsigargin indirectly activate DUSP8 by modulating lipid and calcium signaling pathways that interact with MAPK signaling. Genistein and (-)-Epigallocatechin Gallate, by inhibiting competitive tyrosine kinase and other kinase pathways, allow for a more pronounced activity of DUSP8 within its native signaling pathways. Furthermore, Staurosporine and PMA, through their actions as a broad-spectrum protein kinase inhibitor and PKC activator respectively, modulate other signaling pathways that indirectly enhance the activity of DUSP8. Collectively, these compounds do not directly act on DUSP8 but rather influence a variety of cellular signaling pathways that converge on or interact with the MAPK pathway, where DUSP8 plays a crucial regulatory role. This intricate network of signaling modulation results in the enhanced functional activity of DUSP8, underlining the complex interplay of intracellular signaling pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin increases intracellular cAMP levels, which indirectly activates DUSP8 by stimulating cAMP-dependent protein kinase A (PKA). PKA can then phosphorylate substrates that are relevant to DUSP8's signaling cascade, enhancing its functional activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY 294002, a PI3K inhibitor, indirectly enhances DUSP8 activity by reducing PI3K/AKT pathway signaling, which can have a regulatory effect on MAPK pathways that DUSP8 is involved in, leading to its enhanced activation. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB 203580, a p38 MAPK inhibitor, shifts signaling towards pathways in which DUSP8 is a key player. By inhibiting p38, it allows for the enhanced activity of DUSP8 in its specific signaling routes. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
D-erythro-Sphingosine-1-phosphate influences lipid signaling pathways that intersect with MAPK signaling. Its action can indirectly lead to the activation of DUSP8 by modifying the cellular signaling milieu in which DUSP8 operates. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin raises intracellular calcium levels, thereby activating calcium-dependent signaling pathways that can indirectly enhance DUSP8 activity through cross-talk with MAPK pathways. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, as a tyrosine kinase inhibitor, indirectly enhances DUSP8 activity by reducing competitive signaling from tyrosine kinase pathways, thus allowing DUSP8 pathways to be more active. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
(-)-Epigallocatechin Gallate, a kinase inhibitor, indirectly promotes DUSP8 activation by inhibiting kinases that might otherwise compete with or negatively regulate MAPK pathways, where DUSP8 is a key regulator. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine, a broad-spectrum protein kinase inhibitor, indirectly activates DUSP8 pathways by inhibiting kinases that negatively regulate the MAPK pathways, thereby enhancing DUSP8's role. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA, a PKC activator, indirectly enhances DUSP8 activity by modulating PKC-dependent pathways that intersect with MAPK signaling, thereby influencing DUSP8's functional activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 increases intracellular calcium levels, indirectly enhancing DUSP8's activity through the activation of calcium-dependent signaling pathways that interact with MAPK pathways, where DUSP8 functions. | ||||||