DTYMK Activators
DTYMK Activators are a group of chemicals that can indirectly influence the activity of DTYMK by affecting the availability of its substrates or altering related cellular processes.
Thymidine and Deoxyuridine, for instance, can be metabolized to dTMP, the substrate for DTYMK, thereby indirectly modulating its activity. Other chemicals like Methotrexate, Hydroxyurea, Aminopterin, Pemetrexed, Leucovorin, Trimethoprim, Pyrimethamine, Pralatrexate, and Raltitrexed can affect the synthesis of dTMP by targeting enzymes involved in its biosynthesis, such as thymidylate synthase and dihydrofolate reductase, or by modifying the availability of required cofactors. This can indirectly influence DTYMK activity as it relies on the availability of dTMP. These chemicals provide a means to explore the roles and regulation of DTYMK in cellular processes, particularly in DNA synthesis.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Thymidine | 50-89-5 | sc-296542 sc-296542A sc-296542C sc-296542D sc-296542E sc-296542B | 1 g 5 g 100 g 250 g 1 kg 25 g | $49.00 $73.00 $270.00 $458.00 $1758.00 $114.00 | 16 | |
Thymidine can be metabolized to deoxythymidine monophosphate (dTMP), the substrate for DTYMK. | ||||||
2′-Deoxyuridine | 951-78-0 | sc-216294 sc-216294A | 1 g 5 g | $47.00 $51.00 | ||
Deoxyuridine can be converted to deoxythymidine monophosphate (dTMP), which can be phosphorylated by DTYMK. | ||||||
Aminopterin | 54-62-6 | sc-202461 | 50 mg | $102.00 | 1 | |
Aminopterin can inhibit dihydrofolate reductase, affecting dTMP synthesis and subsequently DTYMK activity. | ||||||
Pemetrexed Disodium | 150399-23-8 | sc-219564 | 10 mg | $136.00 | 5 | |
Pemetrexed can inhibit thymidylate synthase, affecting dTMP availability and indirectly influencing DTYMK activity. | ||||||
Folinic Acid | 58-05-9 | sc-337846A sc-337846B sc-337846 | 5 mg 25 mg 100 mg | $112.00 $297.00 $604.00 | ||
Leucovorin can enhance the availability of reduced folate, indirectly affecting DTYMK activity. | ||||||
Trimethoprim | 738-70-5 | sc-203302 sc-203302A sc-203302B sc-203302C sc-203302D | 5 g 25 g 250 g 1 kg 5 kg | $67.00 $161.00 $255.00 $721.00 $3401.00 | 4 | |
Trimethoprim can inhibit dihydrofolate reductase, affecting dTMP synthesis and subsequently influencing DTYMK activity. | ||||||
Pyrimethamine | 58-14-0 | sc-208190 sc-208190A sc-208190B | 1 g 5 g 25 g | $80.00 $238.00 $825.00 | 5 | |
Pyrimethamine can inhibit dihydrofolate reductase, affecting dTMP synthesis and subsequently DTYMK activity. | ||||||
Folotyn | 146464-95-1 | sc-364491 sc-364491A | 10 mg 50 mg | $480.00 $1455.00 | ||
Pralatrexate can inhibit dihydrofolate reductase, affecting dTMP synthesis and subsequently DTYMK activity. | ||||||
Raltitrexed | 112887-68-0 | sc-219933 | 10 mg | $146.00 | ||
Raltitrexed can inhibit thymidylate synthase, affecting dTMP availability and indirectly influencing DTYMK activity. | ||||||