DPM1 Inhibitors
Chemical inhibitors of DPM1 act through various mechanisms to disrupt the normal function of this protein. Tunicamycin directly inhibits DPM1 by preventing the transfer of N-acetylglucosamine-1-phosphate to dolichol phosphate, a critical step in the synthesis of dolichol-linked oligosaccharides where DPM1 plays a pivotal role. Brefeldin A indirectly targets DPM1 by destabilizing the Golgi structure, impairing the oligosaccharide synthesis and processing that DPM1 is involved in. Similarly, the action of Swainsonine and Kifunensine on mannosidase II and I, respectively, leads to a buildup of improperly processed glycoproteins, which compromises the substrate availability and thus the activity of DPM1. The same principle applies to Deoxynojirimycin and Deoxymannojirimycin, which inhibit various glycosidases, impacting the pool of glycoproteins that serve as substrates for DPM1's enzymatic function.
Further down this cascade, Castanospermine's inhibition of glucosidases results in the accumulation of incorrectly folded glycoproteins, which disrupts the functional spectrum of DPM1 by affecting the glycoprotein maturation process. Salubrinal's ability to inhibit the dephosphorylation of eIF2α indirectly influences DPM1 by reducing the rate of protein synthesis, which in turn affects the availability of substrates for DPM1. Additionally, Endo-β-N-acetylglucosaminidase H modifies the glycoprotein processing by cleaving N-linked oligosaccharides, which can indirectly modulate the function of DPM1 by altering substrate processing. These inhibitors demonstrate a range of approaches to limit the activity of DPM1, from direct blockade of enzymatic activity to indirect effects on the glycoprotein substrates essential for the proper functioning of DPM1.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Tunicamycin inhibits DPM1 directly by blocking the transfer of N-acetylglucosamine-1-phosphate to dolichol phosphate, which is an essential early step in the dolichol-linked oligosaccharide synthesis pathway that DPM1 is a crucial part of. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A disrupts the structure and function of the Golgi apparatus, where DPM1 functions in N-linked glycosylation. This disruption impedes the synthesis of dolichol-linked oligosaccharides, thus indirectly inhibiting the enzymatic activity of DPM1. | ||||||
Swainsonine | 72741-87-8 | sc-201362 sc-201362C sc-201362A sc-201362D sc-201362B | 1 mg 2 mg 5 mg 10 mg 25 mg | $138.00 $251.00 $631.00 $815.00 $1832.00 | 6 | |
Swainsonine inhibits mannosidase II, which leads to accumulation of misprocessed glycoproteins. This buildup indirectly affects DPM1 by altering the availability and structure of the glycoprotein substrates needed for its enzymatic function. | ||||||
Kifunensine | 109944-15-2 | sc-201364 sc-201364A sc-201364B sc-201364C | 1 mg 5 mg 10 mg 100 mg | $135.00 $540.00 $1025.00 $6248.00 | 25 | |
Kifunensine inhibits mannosidase I, leading to the accumulation of high-mannose glycoproteins. This indirectly inhibits DPM1 by changing the pool of glycosylated substrates that are required for its activity. | ||||||
Deoxynojirimycin | 19130-96-2 | sc-201369 sc-201369A | 1 mg 5 mg | $73.00 $145.00 | ||
Deoxynojirimycin inhibits various glycosidases, which can alter the glycoprotein processing pathway. This alteration can influence the substrate availability for DPM1, thereby indirectly inhibiting its function. | ||||||
Deoxymannojirimycin hydrochloride | 84444-90-6 | sc-201360 sc-201360A | 1 mg 5 mg | $93.00 $239.00 | 2 | |
Deoxymannojirimycin, like Deoxynojirimycin, inhibits glycosidases involved in processing glycoproteins, which indirectly influences the substrate availability for DPM1, leading to inhibition of its glycosylation activity. | ||||||
Castanospermine | 79831-76-8 | sc-201358 sc-201358A | 100 mg 500 mg | $184.00 $632.00 | 10 | |
Castanospermine inhibits several glucosidases, which can lead to an accumulation of improperly folded glycoproteins. This accumulation can indirectly inhibit the function of DPM1 by affecting the maturation of glycoproteins it acts upon. | ||||||
Salubrinal | 405060-95-9 | sc-202332 sc-202332A | 1 mg 5 mg | $34.00 $104.00 | 87 | |
Salubrinal indirectly inhibits DPM1 by preventing the dephosphorylation of eIF2α, which reduces overall protein synthesis. This reduction in protein synthesis affects the availability of glycoprotein substrates for DPM1. | ||||||