DOCK11 Activators
DOCK11 Activators represent a class of chemical compounds that indirectly modulate the activity of the DOCK11 (Dedicator of Cytokinesis 11) protein. DOCK11 plays a pivotal role in cellular signaling and cytoskeletal dynamics, and while direct activators of DOCK11 may not be well-established, several chemicals can influence its activation through various signaling pathways. These activators impact DOCK11 by targeting components upstream or downstream of the protein within the intricate cellular signaling network.
One approach involves the use of kinase inhibitors such as Gefitinib, Dasatinib, and Sunitinib. These compounds target various kinases within signaling pathways interconnected with DOCK11, indirectly affecting its activity by disrupting downstream signaling cascades. Similarly, PI3K inhibitors like LY294002 and Wortmannin can influence DOCK11 through the PI3K/AKT pathway, a pathway closely tied to DOCK11 regulation. Additionally, inhibitors like Y-27632 and SB431542, which target Rho-associated protein kinase (ROCK) and TGF-β receptor signaling, respectively, indirectly impact DOCK11 by modulating related pathways. Moreover, inhibitors of mitogen-activated protein kinases (MAPKs), such as U0126 and SB203580, can influence DOCK11 activity through their actions on signaling events associated with DOCK11-mediated processes. Rapamycin, an mTOR inhibitor, can indirectly affect DOCK11 by modulating signaling pathways related to mTOR, intersecting with DOCK11-associated events.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Gefitinib | 184475-35-2 | sc-202166 sc-202166A sc-202166B sc-202166C | 100 mg 250 mg 1 g 5 g | $63.00 $114.00 $218.00 $349.00 | 74 | |
Gefitinib is a tyrosine kinase inhibitor that can affect signaling pathways connected to DOCK11 indirectly, potentially impacting its activation via downstream signaling events. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a phosphoinositide 3-kinase (PI3K) inhibitor, and DOCK11 activity can be influenced through the PI3K/AKT pathway, making this inhibitor relevant to DOCK11 regulation. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $70.00 $145.00 | 51 | |
Dasatinib is a kinase inhibitor that can target various kinases involved in signaling pathways that intersect with DOCK11, indirectly affecting its activation. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a ROCK (Rho-associated protein kinase) inhibitor. DOCK11 activity can be modulated by Rho family GTPases, making ROCK inhibitors relevant to its regulation. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a p38 MAPK (mitogen-activated protein kinase) inhibitor. DOCK11 activity can be influenced by p38 MAPK signaling, making this inhibitor relevant to its regulation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR, which can indirectly affect signaling pathways related to DOCK11 and potentially influence its activation through mTOR-associated events. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a PI3K inhibitor, and DOCK11 activity can be influenced through the PI3K/AKT pathway, making this inhibitor relevant to DOCK11 regulation. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
SB431542 is an inhibitor of TGF-β receptor signaling, which can indirectly affect signaling pathways connected to DOCK11 and potentially influence its activation. | ||||||
Sunitinib Malate | 341031-54-7 | sc-220177 sc-220177A sc-220177B | 10 mg 100 mg 3 g | $197.00 $520.00 $1093.00 | 4 | |
Sunitinib is a multi-kinase inhibitor that can target kinases involved in pathways related to DOCK11, indirectly impacting its activation through downstream signaling events. | ||||||