Dmap1 Activators
Dmap1 activators consist of compounds that indirectly enhance Dmap1's functional activity by modulating chromatin dynamics and DNA repair pathways. Forskolin, through its elevation of cAMP levels, activates PKA, which may phosphorylate substrates that interact with Dmap1, indirectly enhancing Dmap1's chromatin remodeling activities. Epigallocatechin gallate (EGCG) and 5-Azacytidine target the methylation status of DNA, either by inhibiting methyltransferases or incorporating into DNA to reduce methylation, respectively, which could lead to an environment where Dmap1's binding and activity are augmented. Resveratrol, through SIRT1 activation, and Nicotinamide, through SIRT1 inhibition, modulate acetylation states of the chromatin, facilitating Dmap1's access to DNA repair sites. Spermidine, which induces autophagy, and Trichostatin A (TSA), a histone deacetylase, may create favorable conditions for Dmap1's DNA repair mechanisms by affecting protein translation and increasing chromatin accessibility.
Furthermore, Sodium butyrate and SAHA, both histone deacetylase, amplify histone acetylation, loosening chromatin and enhancing Dmap1's activity in DNA repair and replication. Curcumin's inhibition of histone acetyltransferases and Parthenolide's inhibition of NF-κB could lead to alterations in chromatin structure, thereby indirectly promoting Dmap1's functional role. Zebularine, by trapping DNA methyltransferases, and Resveratrol, as a SIRT1 activator, create an epigenetic landscape that supports Dmap1's role in genomic stability. Collectively, these Dmap1 activators work by influencing chromatin architecture and DNA repair pathways, leading to an enhanced functional state of Dmap1 without directly increasing its expression or altering its intrinsic activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, leading to an increase in cAMP levels. Elevated cAMP activates PKA, which can phosphorylate various proteins, potentially enhancing the chromatin remodeling activity of Dmap1 by altering the phosphorylation status of proteins involved in the DNA repair and replication machinery. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a kinase inhibitor with specificity towards DNA methyltransferases. By inhibiting these enzymes, EGCG may reduce methylation levels, creating a more open chromatin state that could facilitate the binding and activity of Dmap1 in DNA repair processes. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
As a SIRT1 activator, resveratrol can lead to the deacetylation of histones, which might create a favorable environment for Dmap1 to bind to DNA and enhance its role in maintaining genomic stability. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $57.00 $607.00 $176.00 | ||
Spermidine induces autophagy and has been shown to lead to the hypusination of eIF5A, which could indirectly enhance the DNA-binding capability of Dmap1 by modulating the translation of proteins involved in DNA repair pathways. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate, another histone deacetylase inhibitor, has similar effects to TSA, possibly enhancing the activity of Dmap1 by increasing chromatin accessibility. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
Nicotinamide inhibits SIRT1, a NAD+-dependent deacetylase, leading to increased acetylation of proteins including histones. This may indirectly enhance Dmap1 activity by altering the chromatin landscape to allow better access to DNA. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin inhibits histone acetyltransferases (HATs), potentially altering chromatin structure and enhancing the functional activity of Dmap1 by making certain DNA regions more accessible. | ||||||
Zebularine | 3690-10-6 | sc-203315 sc-203315A sc-203315B | 10 mg 25 mg 100 mg | $129.00 $284.00 $1004.00 | 3 | |
Zebularine is a cytidine analog that can incorporate into DNA and trap DNA methyltransferases, leading to passive demethylation. This may enhance Dmap1's activity by affecting chromatin structure and function. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $81.00 $306.00 | 32 | |
Parthenolide inhibits NF-κB, a transcription factor that can influence chromatin structure. By inhibiting NF-κB, parthenolide may enhance the activity of Dmap1 by modulating the expression of genes that interact with or regulate Dmap1. | ||||||