DIO2 Inhibitors
DIO2, a crucial enzyme involved in the conversion of thyroxine (T4) to the active form triiodothyronine (T3), can be modulated by various chemical inhibitors. Among these, Iopanoic Acid directly inhibits DIO2 by competing with T4 for binding, impairing the conversion to T3 and impacting thyroid hormone signaling. Propylthiouracil indirectly influences DIO2 by inhibiting thyroid hormone synthesis, blocking the production of T4, the substrate for DIO2-mediated conversion to T3. Dicoumarol, an indirect modulator, influences DIO2 by interfering with vitamin K-dependent carboxylation, altering thyroid hormone-binding protein affinities.
Amiodarone indirectly modulates DIO2 by inhibiting the peripheral conversion of T4 to T3, impacting the substrate availability for DIO2. 6-Propyl-2-thiouracil, Perchlorate, Thiouracil, Iodine, and Methimazole are indirect inhibitors blocking thyroid hormone synthesis, affecting T4 availability and subsequently DIO2-mediated conversion. Bisdionin C, a natural compound, indirectly modulates DIO2 by interfering with thyroid hormone synthesis. PFOA alters thyroid hormone homeostasis, indirectly influencing DIO2 activity. In summary, these DIO2 inhibitors provide valuable tools for studying thyroid hormone regulation and associated cellular processes.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
6-Propyl-2-thiouracil | 51-52-5 | sc-214383 sc-214383A sc-214383B sc-214383C | 10 g 25 g 100 g 1 kg | $36.00 $55.00 $220.00 $1958.00 | ||
Propylthiouracil is an antithyroid drug that indirectly influences DIO2 by inhibiting thyroid hormone synthesis. It blocks the activity of thyroid peroxidase, reducing the production of thyroxine (T4), the substrate for DIO2-mediated conversion to triiodothyronine (T3). This indirect inhibition of DIO2 alters thyroid hormone levels, affecting cellular processes regulated by thyroid hormones. | ||||||
Dicoumarol | 66-76-2 | sc-205647 sc-205647A | 500 mg 5 g | $20.00 $39.00 | 8 | |
Dicoumarol is a coumarin derivative that indirectly modulates DIO2 by influencing the vitamin K-dependent carboxylation of thyroid hormone-binding proteins. By inhibiting vitamin K epoxide reductase, Dicoumarol impairs the carboxylation process, leading to altered binding affinities of thyroid hormones. This indirect modulation affects the availability and activity of thyroid hormones, impacting cellular responses mediated by DIO2. | ||||||
Amiodarone | 1951-25-3 | sc-480089 | 5 g | $312.00 | ||
Amiodarone is an agent in research with antiarrhythmic properties that indirectly influences DIO2 by altering thyroid hormone metabolism. It inhibits the peripheral conversion of thyroxine (T4) to triiodothyronine (T3), impacting the substrate availability for DIO2. This indirect modulation of DIO2 activity can lead to changes in thyroid hormone levels, affecting cellular processes regulated by thyroid hormones. | ||||||
Methimazole | 60-56-0 | sc-205747 sc-205747A | 10 g 25 g | $69.00 $110.00 | 4 | |
Methimazole is a thioamide derivative that indirectly modulates DIO2 by inhibiting thyroid hormone synthesis. It blocks the activity of thyroid peroxidase, reducing the production of thyroxine (T4), the substrate for DIO2-mediated conversion to triiodothyronine (T3). This indirect inhibition of DIO2 alters thyroid hormone levels, affecting cellular processes regulated by thyroid hormones. | ||||||
Pentadecafluorooctanoic acid | 335-67-1 | sc-250662 sc-250662A | 5 g 25 g | $49.00 $149.00 | ||
PFOA is a synthetic compound that indirectly influences DIO2 by altering thyroid hormone homeostasis. It interferes with thyroid hormone transport proteins, affecting the availability of substrates for DIO2-mediated conversion. This indirect modulation can lead to changes in thyroid hormone levels, influencing cellular processes regulated by thyroid hormones and impacting DIO2 activity. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium modulates DIO2 by affecting thyroid hormone metabolism. It inhibits the release of thyroid hormone from the thyroid gland and alters the peripheral conversion of thyroxine (T4) to triiodothyronine (T3). This indirect modulation of DIO2 activity can lead to changes in thyroid hormone levels, affecting cellular processes regulated by thyroid hormones. | ||||||