Dia 2 Activators
The chemical class called Dia 2 Activators encompasses compounds that can indirectly influence the activity of Dia 2 through their effects on actin dynamics, cytoskeletal regulation, and related cellular signaling pathways. These compounds do not directly activate Dia 2; instead, they create cellular conditions or modulate pathways that could enhance Dia 2's functional role in actin filament assembly and regulation.
Compounds such as Jasplakinolide, Cytochalasin D, Latrunculin A, and Phalloidin directly influence actin dynamics by stabilizing or disrupting actin filaments, potentially impacting the role of Dia 2 in actin assembly. Forskolin, by increasing cAMP levels, could modulate signaling pathways relevant to cytoskeletal dynamics and thereby influence Dia 2 activity. Rho Kinase inhibitors like Y-27632, PAK inhibitors like IPA-3, and MLCK inhibitors like ML-7 target specific kinases involved in cytoskeletal regulation, potentially affecting Dia 2's function. Nocodazole and Vinblastine, as microtubule modulators, and compounds like Swinholide A and Blebbistatin, which impact actin-myosin interactions, represent additional mechanisms by which the activity of Dia 2 might be indirectly influenced.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, a catechin found in green tea, has been shown to protect telomeres from degradation. TTI2, being a part of the telomerase complex, would have its functional activity indirectly enhanced by the stabilization of telomere length and structure due to the protective effects of EGCG on telomeres. | ||||||
Astragaloside IV | 84687-43-4 | sc-257103 | 20 mg | $56.00 | 1 | |
Astragaloside IV, a saponin found in Astragalus membranaceus, has been reported to activate telomerase activity. As TTI2 is a component of the telomerase complex, the upregulation of telomerase activity by Astragaloside IV would indirectly enhance the activity of TTI2. | ||||||
Danazol | 17230-88-5 | sc-203021 sc-203021A | 100 mg 250 mg | $90.00 $233.00 | 3 | |
Danazol, a synthetic steroid, has been shown to cause the elongation of telomeres in some cell types. This process could logically require the enhanced function of TTI2 as part of the telomerase complex, indirectly leading to its activation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is a polyphenolic compound that has been associated with the activation of SIRT1, a protein that may protect telomeres through deacetylation of histones. The activation of SIRT1 and subsequent protection of telomere structure could indirectly enhance the functional activity of TTI2 within the telomerase complex. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc is an essential trace element that has been found to be important for maintaining telomere length. Adequate zinc levels can enhance the function of telomerase and therefore indirectly increase the functional activity of TTI2 within the telomerase complex. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Vitamin D3 has been implicated in the regulation of telomere length and telomerase activity. By influencing telomerase activity, Vitamin D3 could indirectly enhance the activity of TTI2 as part of the telomerase complex. | ||||||
Selenium | 7782-49-2 | sc-250973 | 50 g | $61.00 | 1 | |
Selenium is a trace element that has been associated with telomere length maintenance. By contributing to telomere stability, selenium could indirectly enhance the activity of TTI2 within the telomerase complex. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid can influence gene expression patterns and cellular differentiation. These processes might affect the telomere maintenance machinery, indirectly enhancing the activity of TTI2 within the telomerase complex. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $33.00 $73.00 $265.00 $112.00 | 34 | |
NAC, an antioxidant, can mitigate oxidative stress, which has been known to cause telomere attrition. By reducing oxidative stress and telomere shortening, NAC could indirectly enhance the functional activity of TTI2 as part of the telomerase complex. | ||||||
Fucoidan | 9072-19-9 | sc-255187 sc-255187A | 500 mg 10 g | $186.00 $312.00 | 7 | |
Fucoidan, a sulfated polysaccharide, has been reported to have telomerase-activating properties in some studies.The description of the chemical class known as 'TTI2 Activators' involves discussing compounds that would theoretically enhance the activity of the Telomerase-associated protein TTI2. | ||||||