Date published: 2025-10-17

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Derivatization Agents

Santa Cruz Biotechnology now offers a broad range of derivatization agents for use in various applications. Derivatization agents are critical compounds used to chemically modify analytes to enhance their detectability, stability, and chromatographic properties in analytical chemistry. These agents play a crucial role in techniques such as gas chromatography (GC), liquid chromatography (LC), and mass spectrometry (MS), where they help in converting non-volatile, thermally labile, or otherwise undetectable compounds into more amenable forms. Researchers utilize derivatization agents to improve the separation and detection of complex mixtures, enabling precise and accurate analysis of components at trace levels. In scientific research, these agents are employed to study a wide array of substances, including environmental pollutants, food additives and biological molecules. Derivatization can aid in the identification and quantification of amino acids, fatty acids, carbohydrates, and steroids, among others, by enhancing their chromatographic and spectrometric responses. By offering a comprehensive selection of high-quality derivatization agents, Santa Cruz Biotechnology supports advanced research and analytical methodologies across various fields, including biochemistry, environmental science, and forensic analysis. These agents empower scientists to achieve greater sensitivity and specificity in their analytical procedures, driving forward discoveries and innovations in their respective disciplines. View detailed information on our available derivatization agents by clicking on the product name.

Items 221 to 230 of 257 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

tert-Butyldimethylsilyl N-Phenylbenzimidate

404392-70-7sc-296475
5 g
$390.00
(0)

tert-Butyldimethylsilyl N-Phenylbenzimidate acts as a versatile derivatization agent, notable for its ability to enhance the stability of reactive intermediates through silyl protection. Its unique benzimidate moiety facilitates selective nucleophilic attack, promoting efficient reaction kinetics. The tert-butyldimethylsilyl group provides steric hindrance, which can influence reaction pathways and improve yields in complex organic transformations, making it a valuable tool in synthetic chemistry.

ZnAF-2F DA

443302-10-1sc-296862
1 mg
$700.00
(0)

ZnAF-2F DA serves as a potent derivatization agent, characterized by its ability to form stable adducts through unique halogen bonding interactions. This compound exhibits rapid reaction kinetics, enabling efficient derivatization of various substrates. Its distinct reactivity profile allows for selective functionalization, while its physical properties facilitate compatibility with diverse reaction conditions. The compound's behavior as an acid halide enhances its utility in complex synthetic pathways.

2,3,4,6-Tetra-O-pivaloyl-β-D-glucopyranosyl isothiocyanate

958300-06-6sc-288404
100 mg
$208.00
(0)

2,3,4,6-Tetra-O-pivaloyl-β-D-glucopyranosyl isothiocyanate serves as a potent derivatization agent, distinguished by its capacity to form isothiocyanate derivatives through electrophilic interactions. This compound exhibits a strong reactivity towards amines, facilitating the formation of stable thiourea bonds. Its sterically hindered pivaloyl groups enhance selectivity and control in reaction pathways, while its solubility profile allows for compatibility with diverse solvents, optimizing reaction kinetics in various synthetic contexts.

2-(Trimethylsilyl)ethyl 3-Nitro-1H-1,2,4-triazole-1-carboxylate

1001067-09-9sc-287635
sc-287635A
1 g
5 g
$205.00
$712.00
(0)

2-(Trimethylsilyl)ethyl 3-Nitro-1H-1,2,4-triazole-1-carboxylate acts as a versatile derivatization agent, characterized by its ability to engage in nucleophilic substitution reactions. The presence of the nitro group enhances electrophilicity, promoting rapid reaction with nucleophiles. Its trimethylsilyl moiety provides increased stability and solubility, facilitating efficient extraction and purification processes. This compound's unique reactivity profile allows for selective modifications in complex organic syntheses.

(R)-(+)-1-Phenylethanol

1517-69-7sc-250864
sc-250864A
5 g
25 g
$79.00
$281.00
(1)

(R)-(+)-1-Phenylethanol serves as an effective derivatization agent, notable for its chiral nature, which enables enantioselective reactions. Its hydroxyl group can participate in hydrogen bonding, enhancing interactions with electrophiles and facilitating the formation of stable intermediates. The compound's aromatic ring contributes to its hydrophobic character, promoting solubility in organic solvents and enabling selective derivatization in complex mixtures. This unique behavior allows for tailored modifications in synthetic pathways.

Bis(dimethylamino)dimethylsilane

3768-58-9sc-252458
25 g
$48.00
(0)

Bis(dimethylamino)dimethylsilane serves as a potent derivatization agent, notable for its ability to engage in rapid nucleophilic reactions due to its electron-rich dimethylamino groups. This compound exhibits unique reactivity with carbonyl compounds, promoting the formation of stable silyl derivatives. Its silane backbone enhances solubility and compatibility with various solvents, while the steric effects of the dimethylamino groups allow for selective functionalization, streamlining synthetic pathways.

4,5-Dimethoxy-2-nitrobenzyl chloroformate

42855-00-5sc-238989
1 g
$135.00
(1)

4,5-Dimethoxy-2-nitrobenzyl chloroformate is a versatile derivatization agent characterized by its electrophilic chloroformate group, which readily reacts with nucleophiles. The presence of methoxy and nitro substituents enhances its reactivity and selectivity, facilitating the formation of stable esters. Its unique electronic properties promote efficient acylation reactions, while the aromatic structure contributes to favorable solubility in organic solvents, making it an effective tool for modifying functional groups in complex molecules.

(R)-(−)-α-Methoxy-α-(trifluoromethyl)phenylacetyl chloride

39637-99-5sc-253378
100 mg
$66.00
(0)

(R)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetyl chloride is a highly reactive acid chloride known for its distinctive trifluoromethyl group, which significantly influences its electrophilic character. This feature enhances its ability to acylate nucleophiles, leading to the formation of stable derivatives. The methoxy substituent further modulates electronic properties, promoting selective reactions. Its unique structure allows for efficient interactions with various functional groups, making it a powerful agent in chemical transformations.

4-(Bromomethyl)-6,7-dimethoxycoumarin

88404-25-5sc-206768
1 g
$214.00
1
(0)

4-(Bromomethyl)-6,7-dimethoxycoumarin serves as a versatile derivatization agent, characterized by its bromomethyl group that enhances electrophilicity. This feature facilitates nucleophilic substitution reactions, allowing for the formation of diverse derivatives. The presence of methoxy groups contributes to its solubility and reactivity, enabling selective interactions with various functional groups. Its unique coumarin backbone also allows for distinct photophysical properties, making it suitable for innovative chemical applications.

1,1,1,3,3,3-Hexafluoro-2-propanol-d2

38701-74-5sc-224855
1 g
$102.00
(0)

1,1,1,3,3,3-Hexafluoro-2-propanol-d2 is a specialized derivatization agent notable for its strong hydrogen-bonding capabilities and unique fluorinated structure. The presence of multiple fluorine atoms enhances its polarity and reactivity, promoting efficient interactions with nucleophiles. This compound exhibits distinct solvation properties, which can influence reaction kinetics and selectivity in derivatization processes, making it a valuable tool for modifying various substrates in analytical chemistry.