δENaC Inhibitors
Delta (δ) Epithelial Sodium Channel (ENaC) Inhibitors represent a class of chemical compounds designed to target and modulate the activity of δENaC, a subtype of the Epithelial Sodium Channel (ENaC) family. ENaCs are ion channels predominantly expressed in the epithelial cells of various tissues, including the distal nephron of the kidney, respiratory epithelia, and sweat glands. These channels play a pivotal role in sodium ion (Na+) transport across cellular membranes, contributing significantly to the regulation of sodium homeostasis, fluid balance, and blood pressure. The δENaC subtype is a critical component of ENaC and has garnered substantial interest due to its unique regulatory functions and implications in physiology and pathology.
δENaC inhibitors are characterized by their ability to selectively modulate the activity of δENaC subunits within the larger ENaC complex. This selectivity arises from their distinctive chemical structures and mechanisms of action. These inhibitors often interact with specific domains or binding sites on the δENaC protein, interfering with its function. By doing so, they exert a precise and finely tuned influence on sodium transport, which can have a profound impact on the overall sodium balance within the body. Researchers have been particularly interested in δENaC inhibitors for their potential to elucidate the underlying mechanisms of sodium transport and ion channel regulation. Understanding these mechanisms is crucial not only for advancing our knowledge of fundamental cellular processes but also for exploring avenues for interventions in conditions where dysregulated sodium transport plays a role.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Amiloride • HCl | 2016-88-8 | sc-3578 sc-3578A | 25 mg 100 mg | $22.00 $56.00 | 6 | |
Blocks sodium channels on the apical membrane of epithelial cells, inhibiting sodium reabsorption and reducing water absorption in the kidneys. This leads to decreased blood volume and blood pressure. | ||||||
Eplerenone | 107724-20-9 | sc-203943 sc-203943A | 10 mg 50 mg | $108.00 $612.00 | 4 | |
Selective aldosterone receptor antagonist, which decreases sodium and water reabsorption, reducing blood pressure. It primarily acts in the distal tubules and collecting ducts of the kidney. | ||||||
Triamterene | 396-01-0 | sc-213103A sc-213103 | 1 g 5 g | $22.00 $53.00 | ||
Inhibits the epithelial sodium channel (ENaC) in the distal nephron, decreasing sodium reabsorption and water retention. It is often used in combination with other diuretics. | ||||||
Spironolactone | 52-01-7 | sc-204294 | 50 mg | $107.00 | 3 | |
Blocks the action of aldosterone by binding to its receptor, reducing sodium reabsorption and potassium excretion in the distal tubules, and indirectly lowering blood pressure. | ||||||
Tolvaptan | 150683-30-0 | sc-364638 sc-364638A | 10 mg 50 mg | $122.00 $612.00 | ||
A vasopressin V2 receptor antagonist that inhibits water reabsorption in the renal collecting ducts, leading to increased water excretion and a decrease in blood pressure. | ||||||
Indapamide | 26807-65-8 | sc-204777 sc-204777A | 250 mg 1 g | $45.00 $63.00 | ||
A thiazide-like diuretic that inhibits sodium reabsorption in the distal convoluted tubules by blocking sodium-chloride co-transporters, ultimately reducing blood volume and pressure. | ||||||
Furosemide | 54-31-9 | sc-203961 | 50 mg | $40.00 | ||
Inhibits the sodium-potassium-chloride co-transporter (NKCC2) in the thick ascending loop of Henle, preventing sodium and chloride reabsorption and promoting diuresis and blood pressure reduction. | ||||||
Torsemide | 56211-40-6 | sc-213059 | 10 mg | $260.00 | ||
A loop diuretic that inhibits the NKCC2 co-transporter in the ascending loop of Henle, promoting the excretion of sodium, chloride, and water and reducing blood pressure. | ||||||
Hydrochlorothiazide | 58-93-5 | sc-207738 sc-207738A sc-207738B sc-207738C sc-207738D | 5 g 25 g 50 g 100 g 250 g | $54.00 $235.00 $326.00 $551.00 $969.00 | ||
Inhibits the sodium-chloride co-transporter in the distal convoluted tubules, promoting sodium and water excretion and lowering blood pressure. It is commonly used in combination with other antihypertensive agents. | ||||||
Chlorthalidone | 77-36-1 | sc-207427 | 25 mg | $243.00 | 1 | |
Similar to hydrochlorothiazide, it inhibits the sodium-chloride co-transporter in the distal convoluted tubules, leading to increased sodium and water excretion and reduced blood pressure. | ||||||