Date published: 2025-11-1

1-800-457-3801

SCBT Portrait Logo
Seach Input

Indapamide (CAS 26807-65-8)

0.0(0)
Write a reviewAsk a question

Alternate Names:
N-(4-Chloro-3-sulfamoylbenzamido)-2-methylindoline
Application:
Indapamide is an NCCT inhibitor
CAS Number:
26807-65-8
Purity:
≥98%
Molecular Weight:
365.84
Molecular Formula:
C16H16ClN3O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

Indapamide is a non-thiazide sulfonamide diuretic that functions as a diuretic agent in experimental. It acts by inhibiting the reabsorption of sodium and chloride ions in the distal convoluted tubules of the kidneys, leading to increased excretion of water and electrolytes. Indapamide′s mode of action involves binding to the chloride transport protein, resulting in decreased sodium and chloride reabsorption. By interfering with these ion transport processes, indapamide promotes the elimination of excess fluid and electrolytes. This mechanism of action contributes to its role as a diuretic in experimental applications, where it is used to investigate the effects of increased diuresis on various physiological processes. Indapamide′s function as a diuretic agent is attributed to its specific interactions at the molecular level, which result in increased urinary excretion of water and electrolytes.


Indapamide (CAS 26807-65-8) References

  1. Cardiovascular protective properties of indapamide.  |  Campbell, DB. and Brackman, F. 1990. Am J Cardiol. 65: 11H-27H. PMID: 2184650
  2. Analysis of Fixed-Dose Combination of Three Antihypertensive Drugs by a Green and Quality by Design Approach.  |  Mandić-Kovačević, N., et al. 2023. J Chromatogr Sci. 61: 256-268. PMID: 35653715
  3. In Vitro Dissolution Profile of Antihypertensive Mixture: Comparison Between Multivariate Methods and Statistical and Graphical Representation of Different Univariate Spectrophotometric Data.  |  Magdy, R., et al. 2023. J AOAC Int. 106: 624-635. PMID: 36420987
  4. The impact of different diuretics on regression of myocardial reperfusion injury in spontaneously hypertensive rats.  |  Dragasevic, N., et al. 2023. Mol Cell Biochem. 478: 1803-1812. PMID: 36572765
  5. Benefit of treatment based on indapamide mostly combined with perindopril on mortality and cardiovascular outcomes: a pooled analysis of four trials.  |  Chalmers, J., et al. 2023. J Hypertens. 41: 508-515. PMID: 36633311
  6. Incidence of severe hypokalaemia in patients taking indapamide.  |  Lin, Z., et al. 2023. Intern Emerg Med. 18: 549-557. PMID: 36715848
  7. Potential Pharmacokinetic Interactions of Common Cardiovascular Drugs and Selected European and Latin American Herbal Medicines: A Scoping Review.  |  Prieto-Garcia, JM., et al. 2023. Plants (Basel). 12: PMID: 36771707
  8. The Efficacy and Tolerability of a Fixed Combination of Perindopril and Indapamide in the Treatment of Unregulated Essential Hypertension - a Postmarketing Study.  |  Šukalo, A., et al. 2022. Acta Med Acad. 51: 163-174. PMID: 36799308
  9. Association between Food/UGT2B7 Polymorphisms and Pharmacokinetics/Pharmacodynamics Properties of Indapamide in Healthy Humans.  |  Abbas, B., et al. 2023. Biomedicines. 11: PMID: 37239171
  10. Therapeutic Drug Monitoring in Arterial Hypertension.  |  Seleznev, S., et al. 2023. J Pers Med. 13: PMID: 37240985
  11. Gene, cell type, and drug prioritization analysis suggest genetic basis for the utility of diuretics in treating Alzheimer disease.  |  Pinakhina, D., et al. 2023. HGG Adv. 4: 100203. PMID: 37250495
  12. Initial treatment with a single capsule containing half-dose quadruple therapy vs standard-dose dual therapy in hypertensive patients (QUADUAL): Study protocol for a randomized, blinded, crossover trial.  |  Zhao, X., et al. 2023. Am Heart J. 264: 10-19. PMID: 37276913
  13. Efficacy of Allisartan Isoproxil in the Treatment of Mild-to-Moderate Essential Hypertension.  |  Wang, H., et al. 2023. Am J Hypertens.. PMID: 37343187

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Indapamide, 250 mg

sc-204777
250 mg
$45.00

Indapamide, 1 g

sc-204777A
1 g
$63.00