DDX54 Activators
DDX54 activators can be broadly classified as compounds that influence the pathways of RNA synthesis and metabolism, in which DDX54 plays a part. These chemicals interact with the machinery of transcription and translation, thereby indirectly modulating the activity of DDX54. For instance, Actinomycin D and Alpha-Amanitin, by inhibiting RNA synthesis, can affect the pool of RNA molecules available for DDX54 to interact with. Similarly, 5-Azacytidine alters the structure of RNA molecules, which can affect the ability of DDX54 to bind, unwind, or remodel these molecules.
Furthermore, there are compounds such as DRB, Cordycepin, and Triptolide that inhibit RNA polymerase II, a key enzyme in RNA synthesis. By affecting the synthesis of RNA, these compounds can indirectly modulate the activity of DDX54. Leptomycin B changes thelocal concentration of protein substrates and RNA by inhibiting nuclear export, which can also impact the activity of DDX54. Lastly, compounds like Oxaliplatin, Cisplatin, and Rocaglamide, which interfere with the DNA structure and its transcription, can also indirectly influence DDX54 through the subsequent effects on RNA metabolism.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
Alpha-Amanitin inhibits RNA polymerase II, a key enzyme in the synthesis of messenger RNA, microRNA, and small nuclear RNA. By reducing the synthesis of these RNA types, alpha-amanitin can indirectly affect the number of substrates that DDX54 can interact with. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a nucleoside analogue of cytidine that incorporates into RNA and DNA. It alters the methylation patterns of DNA and changes RNA transcription, which indirectly influences the structure of RNA molecules that DDX54 will bind to, unwind, or remodel. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $43.00 $189.00 $316.00 $663.00 | 6 | |
DRB inhibits RNA polymerase II thereby affecting the synthesis of RNA. By reducing the amount of RNA, DRB indirectly affects the number of RNA molecules available for DDX54 to process. | ||||||
Cordycepin | 73-03-0 | sc-203902 | 10 mg | $101.00 | 5 | |
Cordycepin is an adenosine analogue that prematurely terminates transcription when incorporated into RNA. This action can result in a greater amount of incomplete or improperly formed RNA that DDX54 may need to process or repair. | ||||||
Oxaliplatin | 61825-94-3 | sc-202270 sc-202270A | 5 mg 25 mg | $112.00 $394.00 | 8 | |
Oxaliplatin forms intrastrand and interstrand DNA crosslinks, affecting DNA replication and transcription. By influencing these processes, it can indirectly affect the RNA metabolism pathways involving DDX54. | ||||||
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $97.00 $328.00 $676.00 $1467.00 | 6 | |
Rifampicin inhibits DNA-dependent RNA polymerase, impacting the synthesis of RNA. By reducing the amount of RNA, it can indirectly affect the number of RNA molecules available for DDX54 to process. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Triptolide inhibits the transcriptional activity of RNA polymerase II by modulating the XPB subunit of the TFIIH transcription factor. This action reduces the amount of RNA being produced, which in turn can indirectly influence the substrates available for DDX54 to process. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin forms DNA adducts that distort the DNA helix and impair transcription, which can indirectly affect the RNA metabolism pathways involving DDX54. | ||||||
Flavopiridol Hydrochloride | 131740-09-5 | sc-207687 | 10 mg | $317.00 | ||
Flavopiridol is a potent CDK9 inhibitor that suppresses RNA polymerase II-dependent transcription. This action can affect the amount and type of RNA available for DDX54 to process. | ||||||
Rocaglamide | 84573-16-0 | sc-203241 sc-203241A sc-203241B sc-203241C sc-203241D | 100 µg 1 mg 5 mg 10 mg 25 mg | $275.00 $474.00 $1639.00 $2497.00 $5344.00 | 4 | |
Rocaglamide inhibits RNA polymerase II. By inhibiting this enzyme, it affects the overall RNA metabolism, indirectly impacting the function of DDX54. | ||||||