DDX18 Activators
DDX18 is a member of the DEAD-box RNA helicases family that plays a vital role in various aspects of RNA processing and metabolism. These functions include the remodeling of RNA and ribonucleoprotein complexes, RNA transport, RNA decay, ribosome biogenesis, and the initiation of translation. Given that DDX18 operates within the context of RNA metabolism, its activity is inherently tied to the transcriptional and translational status of the cell. Compounds that disrupt or modify these processes can, therefore, indirectly influence DDX18. For instance, Actinomycin D, Alpha-Amanitin, DRB, and Cordycepin are all involved in the alteration of RNA synthesis, either through the direct inhibition of RNA polymerases or the modification of the RNA and DNA structures. By affecting the production and composition of RNA in the cell, these compounds indirectly influence the substrate availability and functional context for DDX18.
In a similar vein, compounds that affect nuclear-cytoplasmic transport, such as Leptomycin B, can indirectly affect DDX18 activity by modulating the cellular localization of its potential substrate proteins. Meanwhile, DNA-damaging agents like Oxaliplatin and Cisplatin can indirectly affect DDX18 by causing changes in the transcriptional landscape of the cell. In addition, compounds like Flavopiridol and Rocaglamide, which inhibit the function of RNA polymerase II, can also indirectly influence DDX18 activity. By inhibiting RNA polymerase II, these compounds affect the synthesis of RNA, thereby influencing the RNA metabolism processes in which DDX18 plays a part.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D binds to the DNA minor groove and interferes with the DNA-dependent RNA polymerase by inhibiting the elongation of RNA chain during transcription. This indirect effect can impact DDX18's role in RNA processing and metabolism. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
α-Amanitin is a potent inhibitor of RNA polymerase II, a key enzyme in the synthesis of messenger RNA, microRNA, and small nuclear RNA. By inhibiting this enzyme, alpha-amanitin affects the overall RNA metabolism, indirectly impacting the function of DDX18. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $43.00 $189.00 $316.00 $663.00 | 6 | |
DRB inhibits RNA polymerase II, thereby affecting the synthesis of RNA. This can indirectly influence the RNA metabolism pathways where DDX18 functions. | ||||||
Cordycepin | 73-03-0 | sc-203902 | 10 mg | $101.00 | 5 | |
Cordycepin is an adenosine analogue that, when incorporated into RNA, results in premature termination of transcription, indirectly affecting DDX18 function in RNA metabolism. | ||||||
Oxaliplatin | 61825-94-3 | sc-202270 sc-202270A | 5 mg 25 mg | $112.00 $394.00 | 8 | |
Oxaliplatin is a platinum-based compound that forms intrastrand and interstrand DNA crosslinks, affecting DNA replication and transcription processes, and thus potentially influencing the RNA metabolism pathways involving DDX18. | ||||||
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $97.00 $328.00 $676.00 $1467.00 | 6 | |
Rifampicin inhibits DNA-dependent RNA polymerase, affecting the synthesis of RNA. This can indirectly influence the RNA metabolism pathways where DDX18 functions. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin forms DNA adducts that distort the DNA helix and impair transcription, potentially influencing the RNA metabolism pathways involving DDX18. | ||||||
Flavopiridol Hydrochloride | 131740-09-5 | sc-207687 | 10 mg | $317.00 | ||
Flavopiridol is a potent CDK9 inhibitor that suppresses RNA polymerase II-dependent transcription, thereby potentially affecting the RNA metabolism processes involving DDX18. | ||||||
Rocaglamide | 84573-16-0 | sc-203241 sc-203241A sc-203241B sc-203241C sc-203241D | 100 µg 1 mg 5 mg 10 mg 25 mg | $275.00 $474.00 $1639.00 $2497.00 $5344.00 | 4 | |
Rocaglamide is a potent inhibitor of RNA polymerase II, a key enzyme in the synthesis of RNA. By inhibiting this enzyme, it affects the overall RNA metabolism, indirectly impacting the function of DDX18. | ||||||