DDA3 Inhibitors
The class of chemicals known as DDA3 inhibitors encompasses a diverse range of compounds that can indirectly affect the function of the DDA3 protein by targeting various cellular processes or signaling pathways. These inhibitors do not bind directly to the DDA3 protein but instead exert their effects on upstream or downstream elements that modulate the activity, stability, or localization of DDA3 within the cell.
The inhibitors listed above affect processes such as microtubule dynamics, DNA synthesis and repair, cell cycle regulation, proteasome-mediated degradation, PI3K/Akt and MAPK/ERK signaling pathways, cytoskeleton organization, cell growth and metabolism, chromatin remodeling, gene expression, protein folding, and calcium signaling. The diversity in the mechanisms of these inhibitors reflects the complexity of cellular systems and highlights the interconnectedness of various cellular components. Each chemical has the capacity to alter the cellular environment or the activity of a range of proteins that, in turn, can influence the function of DDA3. These inhibitors are typically small molecules that can penetrate cell membranes and interact with their specific targets within the cell. Their effects can range from the inhibition of enzyme activity, interference with the structural components of the cell, to the modulation of gene expression. This variety of action mechanisms provides a broad toolkit for researchers to investigate the role of DDA3 in cellular processes and to understand how its function can be modulated indirectly. While the direct targets of these chemicals are well characterized, the indirect effects on DDA3 rely on the assumption of DDA3's involvement in the affected pathways and processes. The use of these inhibitors for studying DDA3 involves careful experimental design to discern specific effects from broader cellular responses to the inhibitors.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Paclitaxel stabilizes microtubules and prevents their depolymerization, which can disrupt mitotic spindle function and cell division. If DDA3 is involved in these processes, paclitaxel can indirectly inhibit its function by preventing proper spindle assembly or dynamics. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $65.00 $99.00 $140.00 | 85 | |
Mitomycin C is a DNA crosslinker that can inhibit DNA replication and transcription. If DDA3 is involved in DNA-related processes, mitomycin C can indirectly inhibit its function by preventing DNA synthesis or repair. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $92.00 $260.00 | 42 | |
Roscovitine is a cyclin-dependent kinase inhibitor that can disrupt cell cycle progression. If DDA3 plays a role in cell cycle regulation, roscovitine can indirectly inhibit its function by halting cell cycle progression at specific checkpoints. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib inhibits the 26S proteasome, leading to the accumulation of polyubiquitinated proteins and potentially affecting protein turnover. If DDA3 is regulated by proteasomal degradation, bortezomib can indirectly inhibit its function by preventing its degradation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that can disrupt multiple signaling pathways related to cell survival, proliferation, and metabolism. If DDA3 is a part of or regulated by PI3K-related pathways, LY294002 can indirectly inhibit its function by blocking PI3K activity. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of the MEK1/2 kinases, which are critical components of the MAPK/ERK signaling pathway. If DDA3 is involved in this pathway, U0126 can indirectly inhibit its function by preventing the activation of ERK and subsequent downstream effects. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a ROCK inhibitor that affects cell shape, motility, and contraction by altering the actin cytoskeleton. If DDA3 is involved in these processes, Y-27632 can indirectly inhibit its function by disrupting the actin cytoskeleton regulation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, a central regulator of cell growth and metabolism. If DDA3 is regulated by or involved in mTOR signaling, rapamycin can indirectly inhibit its function by suppressing mTOR activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another PI3K inhibitor with a mechanism of action similar to LY294002. It can also indirectly inhibit DDA3 function if the protein is associated with PI3K-dependent pathways. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is an HDAC inhibitor that leads to increased acetylation of histones, affecting gene expression. If DDA3 function is modulated by chromatin structure or gene expression, trichostatin A can indirectly inhibit its function by altering transcriptional regulation. | ||||||