DAZ Interacting Zinc Finger Proteins (DZIP) Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $92.00 $204.00 | 19 | |
This is a well-known inhibitor of the Hedgehog signaling pathway, which DZIP is associated with. Cyclopamine specifically targets Smoothened (SMO), a key component of the Hh pathway. | ||||||
Vismodegib | 879085-55-9 | sc-396759 sc-396759A | 10 mg 25 mg | $80.00 $96.00 | 1 | |
Another inhibitor of the Hedgehog pathway, Vismodegib directly targets and inhibits Smoothened. By modulating the Hh pathway, it could indirectly impact DZIP's role in this pathway. | ||||||
Purmorphamine | 483367-10-8 | sc-202785 sc-202785A | 1 mg 5 mg | $56.00 $180.00 | 18 | |
This small molecule activates the Hedgehog pathway by targeting Smoothened. While it is an activator, its interaction with the Hh pathway can indirectly affect DZIP function. | ||||||
Itraconazole | 84625-61-6 | sc-205724 sc-205724A | 50 mg 100 mg | $76.00 $139.00 | 23 | |
A broadly used antifungal agent in research, itraconazole has been found to inhibit the Hedgehog signaling pathway. It offers a unique example of a repurposed drug that could indirectly influence DZIP activity. | ||||||
GANT61 | 500579-04-4 | sc-202630 sc-202630A sc-202630B | 1 mg 5 mg 10 mg | $63.00 $128.00 $200.00 | 6 | |
This molecule specifically inhibits Gli, a transcription factor in the Hedgehog pathway. Given DZIP's connection to Hh signaling, GANT61 might indirectly impact DZIP functions. | ||||||
Jervine | 469-59-0 | sc-200934 sc-200934A | 1 mg 5 mg | $66.00 $240.00 | 1 | |
Similar to cyclopamine, jervine is a naturally occurring Hedgehog pathway inhibitor that targets Smoothened. Its effects on DZIP would be through its modulation of the Hh pathway. | ||||||