Cyp60 Activators
Chemical activators of Cyp60 can influence the protein's functional state through various biochemical interactions. Cyclosporin A, FK506, Sanglifehrin A, and Alisporivir are part of a group of compounds that directly bind to Cyp60 or its family members, leading to conformational changes that can enhance Cyp60's peptidyl-prolyl isomerase activity. The binding of Cyclosporin A to cyclophilins facilitates an inhibitory effect on calcineurin but concurrently stabilizes Cyp60 in an active form. Similarly, FK506 forms a complex with FKBP12, which also inhibits calcineurin while incidentally promoting Cyp60's isomerase activity. Sanglifehrin A and Alisporivir, though distinct in structure, share a similar binding affinity to cyclophilins, culminating in the activation of Cyp60.
On a different note, chemical compounds such as Geldanamycin, Radicicol, 17-AAG, and Novobiocin interact with Hsp90, another chaperone protein, which in turn can indirectly affect Cyp60's activity. Inhibition of Hsp90 by these compounds results in a compensatory increase in the cellular demand for other chaperones, including Cyp60. This compensatory effect can lead to an upregulation and functional activation of Cyp60 as the cell attempts to maintain protein homeostasis. Another compound, Deoxyspergualin, while not as extensively studied, has been shown to bind to immunophilins, which may in turn facilitate the activation of Cyp60. Furthermore, Silmitasertib, a CK2 inhibitor, disrupts normal protein folding and stability processes, which may trigger a stress response involving the activation of various chaperones, including Cyp60
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
Cyclosporin A binds to the cyclophilins, a family of proteins that includes Cyp60, leading to the inhibition of calcineurin. The binding of Cyclosporin A to Cyp60 can stabilize the protein in a conformation that enhances its peptidyl-prolyl isomerase activity, thereby functionally activating Cyp60. | ||||||
FK-506 | 104987-11-3 | sc-24649 sc-24649A | 5 mg 10 mg | $78.00 $151.00 | 9 | |
FK506 binds to FKBP12, creating a complex that inhibits calcineurin. Similar to Cyclosporin A, the binding of FK506 to members of the cyclophilin family, such as Cyp60, can result in a conformational change that enhances the protein's enzymatic activity, effectively activating Cyp60. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin forms a complex with FKBP12, but unlike the FK506-FKBP12 complex that inhibits calcineurin, the rapamycin-FKBP12 complex inhibits mTOR. The inhibition of mTOR can lead to a cellular stress response that indirectly activates chaperones and folding enzymes, including Cyp60, as part of a broader activation of stress response pathways. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
Geldanamycin binds to Hsp90, an important chaperone that assists in protein folding. By binding to Hsp90, Geldanamycin disrupts its function, which can lead to an increased demand for other chaperone proteins, including Cyp60. This increased demand can result in the functional activation of Cyp60 as the cell compensates for the loss of Hsp90 activity. | ||||||
Radicicol | 12772-57-5 | sc-200620 sc-200620A | 1 mg 5 mg | $92.00 $333.00 | 13 | |
Radicicol binds to Hsp90, similarly to Geldanamycin, leading to the inhibition of its chaperone activity. This inhibition can cause a compensatory activation of other chaperones, including Cyp60, to maintain protein homeostasis. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $67.00 $156.00 | 16 | |
17-AAG, an ansamycin antibiotic, binds to Hsp90, inhibiting its activity. The inhibition of Hsp90 activity can trigger an upregulation of other molecular chaperones, including Cyp60, to handle misfolded proteins, thereby enhancing the functional activity of Cyp60. | ||||||
Novobiocin | 303-81-1 | sc-362034 sc-362034A | 5 mg 25 mg | $128.00 $380.00 | ||
Novobiocin also targets Hsp90, albeit at a different binding site than Geldanamycin or Radicicol. By inhibiting Hsp90, Novobiocin can promote the activation of other chaperones, such as Cyp60, to compensate for the reduced chaperoning capacity and maintain proteostasis. | ||||||
CX-4945 | 1009820-21-6 | sc-364475 sc-364475A | 2 mg 50 mg | $183.00 $800.00 | 9 | |
CX-4945 is a casein kinase 2 (CK2) inhibitor. CK2 influences various cellular processes, including protein folding and stability. Inhibition of CK2 can lead to activation of a cellular stress response that may include the upregulation of molecular chaperones like Cyp60, thus functionally activating it. | ||||||