Cyp4f37 Inhibitors
Cyp4f37, a member of the cytochrome P450 family, plays a crucial role in the metabolism of fatty acids within various physiological structures, including the cardiovascular, central nervous, endocrine, genitourinary, and digestive systems. Its diverse expression highlights its significance in maintaining lipid homeostasis and responding to cellular demands. The identified inhibitors exhibit specific mechanisms of action to suppress Cyp4f37 activity. Direct inhibitors such as 1-Aminobenzotriazole, Sulconazole, Clotrimazole, Miconazole, Econazole, Terbinafine, Fluconazole, and Propiconazole interfere directly with the enzyme's heme group or active site, hindering its catalytic function in fatty acid metabolism.
Imidazole acts indirectly by modulating the PI3K/Akt and NF-κB signaling pathways, respectively, disrupting cellular processes regulating Cyp4f37. 4-Methylumbelliferone indirectly influences xenobiotic metabolism, reducing substrate availability for Cyp4f37. Understanding the intricate mechanisms of these inhibitors provides valuable insights into potential strategies for controlling Cyp4f37 activity in diverse physiological contexts. Further research is warranted to explore the implications of manipulating Cyp4f37 and its associated pathways for potential applications in metabolic regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
1-Aminobenzotriazole | 1614-12-6 | sc-200600 sc-200600A | 50 mg 100 mg | $60.00 $131.00 | 6 | |
1-Aminobenzotriazole acts as a direct inhibitor of Cyp4f37 by binding to its active site, disrupting the enzyme's catalytic function in the metabolism of fatty acids. This leads to a targeted inhibition of the protein, hindering its role in lipid homeostasis within various physiological structures. | ||||||
Sulconazole | 61318-90-9 | sc-338599 | 100 mg | $1000.00 | 1 | |
Sulconazole serves as a direct inhibitor of Cyp4f37, interfering with its heme group and thereby suppressing its role in the metabolism of arachidonic acid. This results in a specific inhibition of the protein, impacting its diverse expression in critical systems, including the cardiovascular, central nervous, endocrine, genitourinary, and digestive systems. | ||||||
Clotrimazole | 23593-75-1 | sc-3583 sc-3583A | 100 mg 1 g | $41.00 $56.00 | 6 | |
Clotrimazole acts as a direct inhibitor of Cyp4f37 by binding to its heme group, disrupting the enzyme's catalytic function in the metabolism of fatty acids. This leads to a specific inhibition of the target protein, influencing its expression within the cardiovascular, central nervous, endocrine, genitourinary, and digestive systems, impacting lipid homeostasis. | ||||||
Miconazole | 22916-47-8 | sc-204806 sc-204806A | 1 g 5 g | $65.00 $157.00 | 2 | |
Miconazole functions as a direct inhibitor of Cyp4f37, binding to its heme group and interfering with the enzyme's catalytic function in the metabolism of fatty acids. This results in a targeted inhibition of the protein, affecting its diverse expression across critical physiological structures, including the cardiovascular, central nervous, endocrine, genitourinary, and digestive systems. | ||||||
Econazole | 27220-47-9 | sc-279013 | 5 g | $240.00 | ||
Econazole acts as a direct inhibitor of Cyp4f37 by disrupting the enzyme's heme group, hindering its catalytic activity in the metabolism of arachidonic acid. This leads to a specific inhibition of the protein, influencing its expression in various physiological structures such as the cardiovascular, central nervous, endocrine, genitourinary, and digestive systems, impacting lipid homeostasis. | ||||||
Imidazole | 288-32-4 | sc-204776 sc-204776A sc-204776B sc-204776C | 25 g 100 g 1 kg 5 kg | $26.00 $55.00 $82.00 $336.00 | 2 | |
Imidazole acts as an indirect inhibitor of Cyp4f37 by influencing the PI3K/Akt signaling pathway. Through this modulation, the chemical disrupts the cellular processes that regulate the protein's activity, impacting its expression in critical physiological structures like the cardiovascular, central nervous, endocrine, genitourinary, and digestive systems, thereby influencing lipid homeostasis. | ||||||
Terbinafine | 91161-71-6 | sc-338609 | 100 mg | $560.00 | 1 | |
Terbinafine serves as a direct inhibitor of Cyp4f37, disrupting the enzyme's heme group and impeding its catalytic activity in the metabolism of arachidonic acid. This leads to a specific inhibition of the protein, impacting its expression in diverse physiological structures, including the cardiovascular, central nervous, endocrine, genitourinary, and digestive systems, influencing lipid homeostasis. | ||||||
Fluconazole | 86386-73-4 | sc-205698 sc-205698A | 500 mg 1 g | $53.00 $84.00 | 14 | |
Fluconazole serves as a direct inhibitor of Cyp4f37 by disrupting the enzyme's heme group, hindering its catalytic activity in the metabolism of arachidonic acid. This leads to a specific inhibition of the protein, influencing its expression in various physiological structures, such as the cardiovascular, central nervous, endocrine, genitourinary, and digestive systems, impacting lipid homeostasis. | ||||||
4-Methylumbelliferone | 90-33-5 | sc-206910 sc-206910A sc-206910B sc-206910C sc-206910D | 25 g 100 g 250 g 1 kg 2.5 kg | $34.00 $55.00 $138.00 $423.00 $954.00 | 2 | |
4-Methylumbelliferone indirectly inhibits Cyp4f37 by altering the expression of key genes in the xenobiotic metabolism pathway. This chemical interferes with the enzyme's substrate availability, impeding its catalytic activity. The altered substrate availability impacts the protein's expression in various physiological structures, including the cardiovascular, central nervous, endocrine, genitourinary, and digestive systems, influencing lipid homeostasis. | ||||||