Cyp2c40 Activators
Cyp2c40, a cytochrome P450 enzyme, plays a crucial role as an arachidonic acid 14,15-epoxygenase, influencing eicosanoid synthesis and lipid metabolism. Located in the endoplasmic reticulum and membrane-bound organelles, it is active in the cytoplasm and intracellular membrane-bounded organelles, expressing primarily in the embryo, liver, and metanephros. The gene is implicated in various diseases, including Plasmodium falciparum malaria, eosinophilic esophagitis, glucose metabolism diseases, invasive aspergillosis, and multiple chemical sensitivity.
Activation of Cyp2c40 involves a complex interplay of signaling pathways influenced by various chemicals. Clopidogrel, Carbamazepine, and AUDA directly activate the enzyme, enhancing its 14,15-epoxygenase activity and promoting the production of epoxyeicosatrienoic acids (EETs) with vasodilatory and anti-inflammatory effects. Indirect activators such as GW501516, Indomethacin, and Lornoxicam influence PPAR agonists and COX enzymes, upregulating Cyp2c40 expression and enhancing its arachidonic acid 14,15-epoxygenase activity. Montelukast and Quercetin indirectly activate Cyp2c40 by inhibiting leukotrienes and LOX enzymes, respectively, redirecting arachidonic acid towards epoxygenase pathways. Epinephrine directly activates Cyp2c40, influencing arachidonic acid metabolism and enhancing EETs synthesis. Lovastatin indirectly activates Cyp2c40 by modulating mevalonate pathway intermediates, affecting epoxygenase activities and contributing to the regulation of lipid metabolism. Overall, these chemicals provide insights into potential strategies for modulating Cyp2c40 activation and its role in arachidonic acid metabolism and related diseases.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Clopidogrel | 113665-84-2 | sc-507403 | 1 g | $122.00 | 1 | |
Clopidogrel, an antiplatelet agent, serves as a direct activator of Cyp2c40 by enhancing arachidonic acid 14,15-epoxygenase activity. It specifically stimulates the enzyme's epoxygenase function, leading to increased production of biologically active epoxyeicosatrienoic acids (EETs) that play a role in cardiovascular regulation and inflammation modulation. | ||||||
GW501516 | 317318-70-0 | sc-202642 sc-202642A | 1 mg 5 mg | $82.00 $179.00 | 28 | |
GW501516, a peroxisome proliferator-activated receptor delta (PPARδ) agonist, acts as an indirect activator of Cyp2c40. By activating PPARδ, it upregulates the expression of Cyp2c40, enhancing its arachidonic acid 14,15-epoxygenase activity. This contributes to the modulation of eicosanoid synthesis and lipid metabolism, influencing the production of epoxyeicosatrienoic acids (EETs) with vasodilatory and anti-inflammatory properties. | ||||||
Indomethacin | 53-86-1 | sc-200503 sc-200503A | 1 g 5 g | $29.00 $38.00 | 18 | |
Indomethacin, a nonsteroidal anti-inflammatory drug (NSAID), indirectly activates Cyp2c40 by influencing arachidonic acid metabolism. By inhibiting cyclooxygenase (COX) enzymes, it promotes the redirection of arachidonic acid towards Cyp2c40-mediated epoxygenase pathways, enhancing the synthesis of epoxyeicosatrienoic acids (EETs) with vasodilatory and anti-inflammatory effects. | ||||||
Carbamazepine | 298-46-4 | sc-202518 sc-202518A | 1 g 5 g | $33.00 $71.00 | 5 | |
Carbamazepine, an anticonvulsant, serves as a direct activator of Cyp2c40 by modulating arachidonic acid metabolism. It induces the enzyme's 14,15-epoxygenase activity, leading to increased production of biologically active epoxyeicosatrienoic acids (EETs) that play a role in vasodilation and cardiovascular homeostasis. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine, a neurotransmitter and hormone, directly activates Cyp2c40 by modulating arachidonic acid metabolism. It enhances the enzyme's 14,15-epoxygenase activity, leading to increased production of biologically active epoxyeicosatrienoic acids (EETs) that play a role in cardiovascular regulation and inflammation modulation. | ||||||
WY 14643 | 50892-23-4 | sc-203314 | 50 mg | $136.00 | 7 | |
WY-14643, a PPARα agonist, serves as an indirect activator of Cyp2c40. By activating PPARα, it upregulates the expression of Cyp2c40, enhancing its arachidonic acid 14,15-epoxygenase activity. This contributes to the modulation of eicosanoid synthesis and lipid metabolism, influencing the production of epoxyeicosatrienoic acids (EETs) with vasodilatory and anti-inflammatory properties. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin, a flavonoid, indirectly activates Cyp2c40 by influencing arachidonic acid metabolism. It inhibits lipoxygenase (LOX) enzymes, redirecting arachidonic acid towards Cyp2c40-mediated epoxygenase pathways, enhancing the synthesis of epoxyeicosatrienoic acids (EETs) with vasodilatory and anti-inflammatory properties. | ||||||
Lovastatin | 75330-75-5 | sc-200850 sc-200850A sc-200850B | 5 mg 25 mg 100 mg | $29.00 $90.00 $339.00 | 12 | |
Lovastatin, a HMG-CoA reductase inhibitor, indirectly activates Cyp2c40 by influencing arachidonic acid metabolism. It modulates the levels of mevalonate pathway intermediates, affecting Cyp2c40-mediated epoxygenase activities and contributing to the regulation of eicosanoid synthesis and lipid metabolism. | ||||||
GW 7647 | 265129-71-3 | sc-203068A sc-203068 sc-203068B sc-203068C | 1 mg 5 mg 10 mg 25 mg | $49.00 $170.00 $267.00 $661.00 | 6 | |
GW7647, a PPARα agonist, indirectly activates Cyp2c40. By activating PPARα, it upregulates the expression of Cyp2c40, enhancing its arachidonic acid 14,15-epoxygenase activity. This contributes to the modulation of eicosanoid synthesis and lipid metabolism, influencing the production of epoxyeicosatrienoic acids (EETs) with vasodilatory and anti-inflammatory properties. | ||||||