Cyp2c38 Activators
Cyp2c38, a member of the cytochrome P450 family, plays a pivotal role in arachidonic acid metabolism, specifically as an arachidonic acid 11,12-epoxygenase and arachidonic acid 14,15-epoxygenase. Located in the endoplasmic reticulum and membrane-bound organelles, it exhibits crucial activities in the cytoplasm and intracellular membrane-bounded organelles. The gene is implicated in various diseases, including Plasmodium falciparum malaria, eosinophilic esophagitis, glucose metabolism diseases, invasive aspergillosis, and multiple chemical sensitivity. Activation of Cyp2c38 involves a complex interplay of signaling pathways influenced by various chemicals. Clopidogrel directly activates the enzyme, enhancing arachidonic acid metabolism and regulating platelet aggregation. Indirect activators such as Indomethacin and Lornoxicam redirect arachidonic acid towards Cyp2c38-mediated epoxygenase pathways by inhibiting cyclooxygenase, modulating eicosanoid synthesis. Carbamazepine, AUDA, and Montelukast directly or indirectly stimulate Cyp2c38, leading to increased epoxyeicosatrienoic acids (EETs) production, contributing to vasodilation and anti-inflammatory effects. Epinephrine directly activates Cyp2c38, modulating arachidonic acid metabolism and influencing cardiovascular regulation.
WY-14643 and GW501516 serve as indirect activators by activating PPARα and PPARδ, respectively, upregulating Cyp2c38 expression and enhancing arachidonic acid epoxygenase activities. Quercetin and Zileuton indirectly activate Cyp2c38 by inhibiting LOX and 5-LOX, respectively, promoting the redirection of arachidonic acid towards epoxygenase pathways. Lovastatin influences lipid metabolism and Cyp2c38-mediated epoxygenase activities. Overall, these chemicals highlight the intricate network of pathways influencing Cyp2c38 activation, providing insights into potential strategies for modulating arachidonic acid metabolism and related diseases.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Clopidogrel | 113665-84-2 | sc-507403 | 1 g | $122.00 | 1 | |
Clopidogrel, an antiplatelet agent, serves as a direct activator of Cyp2c38 by enhancing arachidonic acid metabolism. It specifically stimulates the enzyme's arachidonic acid 11,12-epoxygenase and 14,15-epoxygenase activities, leading to increased eicosanoid production and regulation of platelet aggregation. | ||||||
Indomethacin | 53-86-1 | sc-200503 sc-200503A | 1 g 5 g | $29.00 $38.00 | 18 | |
Indomethacin, a nonsteroidal anti-inflammatory drug (NSAID), indirectly activates Cyp2c38 by influencing the arachidonic acid metabolic process. It inhibits cyclooxygenase (COX) enzymes, redirecting arachidonic acid towards Cyp2c38-mediated epoxygenase pathways, resulting in enhanced eicosanoid synthesis. | ||||||
Carbamazepine | 298-46-4 | sc-202518 sc-202518A | 1 g 5 g | $33.00 $71.00 | 5 | |
Carbamazepine, an anticonvulsant, serves as a direct activator of Cyp2c38 by modulating arachidonic acid metabolism. It induces the enzyme's epoxygenase activities, leading to increased production of epoxyeicosatrienoic acids (EETs), which play a role in vasodilation and cardiovascular homeostasis. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine, a neurotransmitter and hormone, directly activates Cyp2c38 by modulating arachidonic acid metabolism. It enhances the enzyme's epoxygenase activities, leading to increased production of epoxyeicosatrienoic acids (EETs), which play a role in cardiovascular regulation and the modulation of inflammatory responses. | ||||||
WY 14643 | 50892-23-4 | sc-203314 | 50 mg | $136.00 | 7 | |
WY-14643, a peroxisome proliferator-activated receptor alpha (PPARα) agonist, serves as an indirect activator of Cyp2c38. By activating PPARα, it upregulates the expression of Cyp2c38, enhancing its epoxygenase activities and contributing to the modulation of arachidonic acid metabolism and the synthesis of biologically active metabolites. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin, a flavonoid, indirectly activates Cyp2c38 by influencing the arachidonic acid metabolic process. It inhibits lipoxygenase (LOX) enzymes, redirecting arachidonic acid towards Cyp2c38-mediated epoxygenase pathways, leading to enhanced synthesis of epoxyeicosatrienoic acids (EETs) with vasodilatory and anti-inflammatory properties. | ||||||
Lovastatin | 75330-75-5 | sc-200850 sc-200850A sc-200850B | 5 mg 25 mg 100 mg | $29.00 $90.00 $339.00 | 12 | |
Lovastatin, a HMG-CoA reductase inhibitor, indirectly activates Cyp2c38 by influencing arachidonic acid metabolism. It modulates the levels of mevalonate pathway intermediates, affecting Cyp2c38-mediated epoxygenase activities and contributing to the regulation of eicosanoid synthesis and lipid metabolism. | ||||||
GW501516 | 317318-70-0 | sc-202642 sc-202642A | 1 mg 5 mg | $82.00 $179.00 | 28 | |
GW501516, a peroxisome proliferator-activated receptor delta (PPARδ) agonist, serves as an indirect activator of Cyp2c38. By activating PPARδ, it upregulates the expression of Cyp2c38, enhancing its arachidonic acid epoxygenase activities and contributing to the modulation of eicosanoid synthesis and lipid metabolism. | ||||||
Zileuton | 111406-87-2 | sc-204417 sc-204417A sc-204417B sc-204417C | 10 mg 50 mg 1 g 75 g | $84.00 $307.00 $369.00 $1254.00 | 8 | |
Zileuton, a 5-lipoxygenase (5-LOX) inhibitor, indirectly activates Cyp2c38 by influencing arachidonic acid metabolism. By blocking the effects of 5-LOX, it promotes the redirection of arachidonic acid towards Cyp2c38-mediated epoxygenase pathways, leading to increased synthesis of epoxyeicosatrienoic acids (EETs) with anti-inflammatory properties. | ||||||