CYP2B10 Activators
Compounds like Phenobarbital, Rifampicin, and Omeprazole act as CYP2B10 Activators, they enhance CYP2B10 activity by inducing its expression. This induction is typically mediated through the activation of liver nuclear receptors such as PXR and CAR, which regulate the transcription of cytochrome P450 genes. Similarly, Dexamethasone and Clofibrate induce CYP2B10 expression through glucocorticoid receptor-dependent mechanisms and activation of PPARs, respectively. These processes lead to an increased capacity of CYP2B10 to metabolize various substrates, including drugs and endogenous compounds.
In addition to these inducers, other compounds like Secobarbital, Citrus Flavonoids, and Clotrimazole modulate CYP2B10 activity by interacting with liver enzymes and influencing metabolic pathways.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $97.00 $328.00 $676.00 $1467.00 | 6 | |
Rifampicin is an antibiotic that can induce CYP2B10 expression by activating nuclear receptors like PXR, leading to increased enzymatic activity of CYP2B10 in drug metabolism. | ||||||
Omeprazole | 73590-58-6 | sc-202265 | 50 mg | $67.00 | 4 | |
Omeprazole, a proton pump inhibitor, can induce CYP2B10 expression. Its effect on CYP2B10 activity is mediated by the activation of liver nuclear receptors that regulate the expression of cytochrome P450 enzymes. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone, a synthetic glucocorticoid, can enhance CYP2B10 activity by inducing its expression. This is mediated through glucocorticoid receptor-dependent mechanisms affecting cytochrome P450 regulation. | ||||||
Clofibrate | 637-07-0 | sc-200721 | 1 g | $33.00 | ||
Clofibrate, a lipid-lowering drug, can induce CYP2B10 expression. It activates peroxisome proliferator-activated receptors (PPARs), which play a role in the regulation of cytochrome P450 enzymes. | ||||||
Clotrimazole | 23593-75-1 | sc-3583 sc-3583A | 100 mg 1 g | $42.00 $57.00 | 6 | |
Clotrimazole, an antifungal agent in research, can induce CYP2B10 expression. It interacts with liver enzymes, leading to altered regulation of cytochrome P450 enzymes including CYP2B10. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin, found in chili peppers, can modulate CYP2B10 activity. It can influence liver enzyme function, potentially affecting CYP2B10's role in metabolism. | ||||||