CYP26C1 Activators

CYP26C1 Activators encompasses a range of compounds that can indirectly influence the activity of Cytochrome P450 26C1 (CYP26C1), an enzyme primarily involved in the catabolism of retinoic acid (RA). Retinoic acid, a metabolite of Vitamin A, plays a vital role in cell differentiation, embryonic development, and the regulation of gene expression. CYP26C1 helps maintain retinoic acid homeostasis by degrading excess RA. The chemicals listed here do not directly activate CYP26C1 but influence the enzyme's activity by altering the levels of retinoic acid or modulating retinoid signaling pathways.

Retinoids like Tretinoin, Isotretinoin, and Bexarotene are involved in the retinoic acid signaling pathway. By binding to retinoic acid receptors or retinoid X receptors, these compounds can alter the levels of retinoic acid in cells, subsequently influencing the activity of CYP26C1, which regulates RA levels. Similarly, synthetic retinoids such as Acitretin, Am580, Adapalene, Fenretinide, Palovarotene, and Alitretinoin can modulate retinoid signaling pathways, thereby indirectly affecting CYP26C1.