Cyp21a1 Activators
Cyp21a1 encodes a protein predicted to have 17-hydroxyprogesterone 21-hydroxylase, heme binding, and progesterone 21-hydroxylase activities, and is involved in progesterone metabolic and steroid biosynthetic processes. It is located in the endoplasmic reticulum and membrane and is expressed in various tissues, including the adrenal gland, lung, metanephros, spleen, and testis. The human ortholog, CYP21A2, is implicated in congenital adrenal hyperplasia.
Activation of Cyp21a1 involves complex regulation through direct and indirect mechanisms. Direct activators may include compounds that directly impact the enzymatic activity of Cyp21a1 or its heme-binding capabilities. For example, the steroidogenesis inhibitor Ketoconazole targets cytochrome P450 enzymes, potentially suppressing Cyp21a1 activity by interfering with steroid biosynthetic pathways. On the other hand, indirect activators may modulate signaling pathways involved in steroidogenesis, affecting Cyp21a1 expression and function. The adenylate cyclase activator Forskolin, for instance, influences cAMP levels, potentially activating Cyp21a1 by impacting progesterone metabolic processes and steroid biosynthetic pathways. Overall, the regulation of Cyp21a1 is intricately linked to steroid hormone synthesis, and its activation or suppression involves a network of signaling cascades and cellular processes. Understanding these activation mechanisms provides insights into the intricate regulatory networks governing steroidogenesis and the role of Cyp21a1 in these processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Aminoglutethimide | 125-84-8 | sc-207280 sc-207280A sc-207280B sc-207280C | 1 g 5 g 25 g 100 g | $42.00 $146.00 $541.00 $2060.00 | 2 | |
Aromatase inhibitor impacting steroid biosynthesis, potentially indirectly enhancing Cyp21a1 activity. Modulates the conversion of progesterone to 17-hydroxyprogesterone, impacting steroidogenic pathways that influence Cyp21a1 function in adrenal gland and other tissues. | ||||||
Ketoconazole | 65277-42-1 | sc-200496 sc-200496A | 50 mg 500 mg | $63.00 $265.00 | 21 | |
Steroidogenesis inhibitor targeting cytochrome P450 enzymes, potentially indirectly suppressing Cyp21a1 activity. Alters the synthesis of steroid hormones, influencing pathways involved in progesterone metabolic processes and impacting Cyp21a1-mediated steroid biosynthesis. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
cAMP analog influencing steroidogenesis, potentially activating Cyp21a1. Modulates cellular signaling cascades, including PKA, impacting progesterone metabolic processes and steroid biosynthetic pathways that involve Cyp21a1. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Glucocorticoid receptor agonist influencing steroidogenesis, potentially suppressing Cyp21a1 activity. Modulates the synthesis of steroid hormones, affecting progesterone metabolic processes and pathways related to Cyp21a1-mediated steroid biosynthesis. | ||||||
Angiotensin II, Human | 4474-91-3 | sc-363643 sc-363643A sc-363643B sc-363643C | 1 mg 5 mg 25 mg 100 mg | $51.00 $100.00 $310.00 $690.00 | 3 | |
Hormonal activator influencing steroidogenesis, potentially activating Cyp21a1. Impacts the renin-angiotensin system, indirectly modulating steroid hormone synthesis and pathways associated with Cyp21a1-mediated steroid biosynthesis. | ||||||
Vitamin K3 | 58-27-5 | sc-205990B sc-205990 sc-205990A sc-205990C sc-205990D | 5 g 10 g 25 g 100 g 500 g | $26.00 $36.00 $47.00 $136.00 $455.00 | 3 | |
NADPH quinone oxidoreductase inhibitor influencing redox balance, potentially affecting Cyp21a1. Alters cellular redox status, indirectly impacting steroidogenesis and progesterone metabolic processes associated with Cyp21a1-mediated steroid biosynthesis. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $59.00 $173.00 | 15 | |
Calcium channel blocker influencing steroidogenesis, potentially suppressing Cyp21a1 activity. Modulates calcium-dependent signaling cascades, impacting progesterone metabolic processes and pathways associated with Cyp21a1-mediated steroid biosynthesis. | ||||||
O-(Carboxymethyl)hydroxylamine hemihydrochloride | 2921-14-4 | sc-207410B sc-207410 sc-207410A | 250 mg 1 g 10 g | $55.00 $107.00 $320.00 | ||
Amino acid analog influencing steroidogenesis, potentially activating Cyp21a1. Modulates cellular metabolism, indirectly impacting progesterone metabolic processes and pathways associated with Cyp21a1-mediated steroid biosynthesis. | ||||||
Mitotane | 53-19-0 | sc-205754 sc-205754A | 100 mg 1 g | $72.00 $166.00 | 1 | |
Adrenal cytotoxic agent impacting steroidogenesis, potentially suppressing Cyp21a1 activity. Modulates adrenal function and steroid hormone synthesis, affecting progesterone metabolic processes and pathways associated with Cyp21a1-mediated steroid biosynthesis. | ||||||
Tamoxifen | 10540-29-1 | sc-208414 | 2.5 g | $272.00 | 18 | |
Selective estrogen receptor modulator potentially influencing Cyp21a1. Modulates estrogen receptor signaling, indirectly impacting steroidogenesis and progesterone metabolic processes associated with Cyp21a1-mediated steroid biosynthesis. | ||||||